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Morphological Pathways of Mitochondrial Division
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Antioxidants 2018, 7(12), 186; https://doi.org/10.3390/antiox7120186

Mitochondrial Membrane Dynamics—Functional Positioning of OPA1

Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
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Received: 15 November 2018 / Revised: 4 December 2018 / Accepted: 6 December 2018 / Published: 8 December 2018
(This article belongs to the Special Issue Mitochondrial Shape Change in Physio-Pathology)
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Abstract

The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion. One of them, optic atrophy 1 (OPA1), is the mitochondrial inner membrane remodeling protein. OPA1 has a dual role in maintaining mitochondrial morphology and energetics through mediating inner membrane fusion and maintaining the cristae structure. OPA1 is expressed in multiple variant forms through alternative splicing and post-translational proteolytic cleavage, but the functional differences between these variants have not been completely understood. Recent studies generated new information regarding the role of OPA1 cleavage. In this review, we will first provide a brief overview of mitochondrial membrane dynamics by describing fission and fusion that are mediated by mitochondrial dynamins. The second part describes OPA1-mediated fusion and energetic maintenance, the role of OPA1 cleavage, and a new development in OPA1 function, in which we will provide new insight for what OPA1 does and what proteolytic cleavage of OPA1 is for. View Full-Text
Keywords: mitochondria; mitochondrial dynamics; fission; fusion; Oxidative phosphorylation (OXPHOS); OPA1; cristae; Overlapping activity with m-AAA protease 1 (OMA1); cardiolipin mitochondria; mitochondrial dynamics; fission; fusion; Oxidative phosphorylation (OXPHOS); OPA1; cristae; Overlapping activity with m-AAA protease 1 (OMA1); cardiolipin
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Lee, H.; Yoon, Y. Mitochondrial Membrane Dynamics—Functional Positioning of OPA1. Antioxidants 2018, 7, 186.

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