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Antioxidant and Chemopreventive Effect of Aliophen® Formulation Based on Malts and Hops

1
National Research Council, Institute of Food Sciences, 83100 Avellino, Italy
2
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy
3
ALIOPHARM S.r.l., 20124 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors equally contributed to this work.
Antioxidants 2021, 10(1), 29; https://doi.org/10.3390/antiox10010029
Received: 25 November 2020 / Revised: 18 December 2020 / Accepted: 22 December 2020 / Published: 30 December 2020
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
Experimental and clinical studies evidenced the health effects of moderate consumption of beer, mainly due to the presence of bioactive compounds, such as polyphenols, vitamins, or fibers. To exploit the potential beneficial effect on health and in disease prevention of these compounds, a new beverage based on barley malts and hops named Aliophen® has been designed, through a patented production process, with a high total polyphenolic amount compared to alcohol-free beer and similar to the one present in light and dark beers. In the present study, the antioxidant activity of Aliophen® against low-density lipoprotein (LDL) oxidation and its ability to protect erythrocytes from hemolysis have been characterized. Moreover, the chemopreventive effect of Aliophen® against colon cancer has been assessed, employing a mouse model of chemically induced carcinogenesis using azoxymethane (AOM). Data obtained showed that Aliophen at a low dose (3 mg/kg) inhibited the formation of preneoplastic lesions, polyps, and tumors. At higher doses (300 mg/kg) the protective effect was measured in the first phase of the onset of cancer. The antioxidant properties of Aliophen® were also observed in AOM-treated mice where it increased the serum antioxidant capacity. Based on the data presented, Aliophen® can exert promising health effects, including an anticancer capacity presumably associated with its antioxidant properties. View Full-Text
Keywords: alcohol-free beer; polyphenols; antioxidant; colon cancer; chemoprevention alcohol-free beer; polyphenols; antioxidant; colon cancer; chemoprevention
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MDPI and ACS Style

Tedesco, I.; Spagnuolo, C.; Bilotto, S.; Izzo, A.A.; Borrelli, F.; Rigano, D.; Russo, M.; Tarricone, F.; Russo, G.L. Antioxidant and Chemopreventive Effect of Aliophen® Formulation Based on Malts and Hops. Antioxidants 2021, 10, 29. https://doi.org/10.3390/antiox10010029

AMA Style

Tedesco I, Spagnuolo C, Bilotto S, Izzo AA, Borrelli F, Rigano D, Russo M, Tarricone F, Russo GL. Antioxidant and Chemopreventive Effect of Aliophen® Formulation Based on Malts and Hops. Antioxidants. 2021; 10(1):29. https://doi.org/10.3390/antiox10010029

Chicago/Turabian Style

Tedesco, Idolo, Carmela Spagnuolo, Stefania Bilotto, Angelo A. Izzo, Francesca Borrelli, Daniela Rigano, Maria Russo, Fabrizio Tarricone, and Gian Luigi Russo. 2021. "Antioxidant and Chemopreventive Effect of Aliophen® Formulation Based on Malts and Hops" Antioxidants 10, no. 1: 29. https://doi.org/10.3390/antiox10010029

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