Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout

Wu, Kun; Cleveland, Beth M.; Portman, Mark; Sealey, Wendy M.; Lei, Xin Gen

doi:10.3390/antiox10010016

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Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout

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Department of Animal Science, Cornell University, Ithaca, NY 14853, USA

USDA/ARS National Center for Cool and Cold Water Research, Leetown, WV 25430, USA

US Fish and Wildlife Service Bozeman Fish Technology Center, Bozeman, MT 59715, USA

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Antioxidants 2021, 10(1), 16; https://doi.org/10.3390/antiox10010016

Received: 30 October 2020 / Revised: 18 December 2020 / Accepted: 23 December 2020 / Published: 27 December 2020

(This article belongs to the Special Issue Antioxidant Defences and Redox Homeostasis in Animals)

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Abstract

Microalgal docosahexaenoic acid (DHA) and astaxanthin (AST) may substitute for fish oil and synthetic AST in aquafeeds. This study explored the effects and mechanisms of those substitutions on AST metabolism and redox status of rainbow trout fed plant protein meal (PM)- or fishmeal (FM)-based diets. Two parallel experiments (PM vs. FM) were performed with 612 juvenile rainbow trout for 16 weeks as a 2 × 3 factorial arrangement of treatments with two AST sources (synthetic (SA) vs. microalgal (AA), at 80 mg/kg) and three levels (0, 50, and 100%) of fish oil substitutions with DHA-rich microalgae. The fish oil substitutions exhibit main effects (p < 0.05) and/or interactive effects (p < 0.05) with the source of AST on AST deposition, malondialdehyde and glutathione concentrations, and mRNA levels and activities of major redox enzymes (glutathione reductase (GR), glutathione peroxidase (GPX), glutathione S-transferase (GST), and superoxide dismutase (SOD)) in the muscle and liver of trout fed both diet series. The AST source produced only differences in tissue AST deposition (p < 0.05) and number of metabolites. In conclusion, the substitutions of fish oil by the DHA-rich microalgae exerted more impacts than those of SA by AA on redox status and functional expression of antioxidant enzymes in the tissues of rainbow trout. View Full-Text

Keywords: algae; astaxanthin; n-3 fatty acid; redox status; trout

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Wu, K.; Cleveland, B.M.; Portman, M.; Sealey, W.M.; Lei, X.G. Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout. Antioxidants 2021, 10, 16. https://doi.org/10.3390/antiox10010016

AMA Style

Wu K, Cleveland BM, Portman M, Sealey WM, Lei XG. Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout. Antioxidants. 2021; 10(1):16. https://doi.org/10.3390/antiox10010016

Chicago/Turabian Style

Wu, Kun, Beth M. Cleveland, Mark Portman, Wendy M. Sealey, and Xin G. Lei. 2021. "Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout" Antioxidants 10, no. 1: 16. https://doi.org/10.3390/antiox10010016

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Supplemental Microalgal DHA and Astaxanthin Affect Astaxanthin Metabolism and Redox Status of Juvenile Rainbow Trout

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