Next Article in Journal
Objective Patterns of Face Recognition Deficits in 165 Adults with Self-Reported Developmental Prosopagnosia
Previous Article in Journal
Four Social Brain Regions, Their Dysfunctions, and Sequelae, Extensively Explain Autism Spectrum Disorder Symptomatology
Previous Article in Special Issue
Effects of GLP-1 Receptor Activation on a Pentylenetetrazole—Kindling Rat Model
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview

Major Depressive Disorder Is Associated with Impaired Interoceptive Accuracy: A Systematic Review

1
Faculty Social Work, Health and Nursing, University of Applied Sciences Ravensburg-Weingarten, 88250 Weingarten, Germany
2
Department of Psychiatry and Psychotherapy I, Ulm University, 88214 Ravensburg (Center for Psychiatry Südwürttemberg), Germany
3
Drug Commission of the German Medical Association, 10623 Berlin, Germany
4
Charité Universitätsmedizin Berlin, 10117 Berlin, Germany
5
Brandenburg Medical School Theodor Fontane, 16816 Neuruppin, Germany
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(6), 131; https://doi.org/10.3390/brainsci9060131
Received: 11 April 2019 / Revised: 30 May 2019 / Accepted: 1 June 2019 / Published: 6 June 2019
(This article belongs to the Collection Collection on Clinical Neuroscience)
  |  
PDF [575 KB, uploaded 6 June 2019]
  |  

Abstract

Interoception is the sense of the physiological condition of the entire body. Impaired interoception has been associated with aberrant activity of the insula in major depressive disorder (MDD) during heartbeat perception tasks. Despite clinical relevance, studies investigating interoceptive impairments in MDD have never been reviewed systematically according to the guidelines of the PRISMA protocol, and therefore we collated studies that assessed accuracy in detecting heartbeat sensations (interoceptive accuracy, IAc) in MDD (databases: PubMed/Medline, PsycINFO, and PsycARTICLES). Out of 389 records, six studies met the inclusion criteria. The main findings suggest that (i) moderately depressed samples exhibit the largest interoceptive deficits as compared with healthy adults. (ii) difficulties in decision making and low affect intensity are correlated with low IAc, and (iii) IAc seems to normalize in severely depressed subjects. These associations may be confounded by sex, anxiety or panic disorder, and intake of selective serotonin reuptake inhibitors. Our findings have implications for the development of interoceptive treatments that might relieve MDD-related symptoms or prevent relapse in recurrent depression by targeting the interoceptive nervous system. View Full-Text
Keywords: major depressive disorder; interoception; heartbeat perception; somatic signals major depressive disorder; interoception; heartbeat perception; somatic signals
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Eggart, M.; Lange, A.; Binser, M.J.; Queri, S.; Müller-Oerlinghausen, B. Major Depressive Disorder Is Associated with Impaired Interoceptive Accuracy: A Systematic Review. Brain Sci. 2019, 9, 131.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top