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Immunotherapy for Pediatric Brain Tumors
Open AccessCommunication

4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma

1
Sanford Children’s Health Research Center, Department of Pediatrics, Cancer Biology and Immunotherapies, Sanford Research, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
2
Biomedical Engineering Department, University of South Dakota, Vermillion, SD 57069, USA
3
4SC AG, Fraunhoferstraße 22, 82152 Planegg, Germany
4
Immunic AG, Am Klopferspitz 19, 82152 Planegg, Germany
*
Author to whom correspondence should be addressed.
Brain Sci. 2017, 7(11), 147; https://doi.org/10.3390/brainsci7110147
Received: 31 August 2017 / Revised: 20 October 2017 / Accepted: 23 October 2017 / Published: 3 November 2017
(This article belongs to the Special Issue Advances in Adult and Pediatric Brain Tumor Management)
This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7). View Full-Text
Keywords: 4SC-202; medulloblastoma; pediatric brain tumor; microarray; bioinformatics 4SC-202; medulloblastoma; pediatric brain tumor; microarray; bioinformatics
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Messerli, S.M.; Hoffman, M.M.; Gnimpieba, E.Z.; Kohlhof, H.; Bhardwaj, R.D. 4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma. Brain Sci. 2017, 7, 147.

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