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Brain Sci. 2016, 6(4), 64;

Genetic Pathways to Insomnia

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Author to whom correspondence should be addressed.
Academic Editor: Célyne H. Bastien
Received: 14 October 2016 / Revised: 14 December 2016 / Accepted: 16 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue New Research in Insomnia)
Full-Text   |   PDF [250 KB, uploaded 20 December 2016]


This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a discussion of the insomnia genetics literature with regard to each of the following common methodologies: twin and family studies, candidate gene studies, and genome-wide association studies (GWAS). Next, we summarize the most recent gene identification efforts (primarily GWAS results) and propose several potential mechanisms through which identified genes may contribute to the disorder. Finally, we discuss new genetic approaches and how these may prove useful for insomnia, proposing an agenda for future insomnia genetics research. View Full-Text
Keywords: insomnia; genetics; genome-wide association study insomnia; genetics; genome-wide association study
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lind, M.J.; Gehrman, P.R. Genetic Pathways to Insomnia. Brain Sci. 2016, 6, 64.

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