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Brain Sci. 2016, 6(3), 35;

The Use of Deep Brain Stimulation in Tourette Syndrome

Institute of Neurology, University College London (UCL), Queen Square, London WC1N 3BG, UK
Sobell Department of Motor Neuroscience, University College London (UCL) Institute of Neurology, London WC1N 3BG, UK
Author to whom correspondence should be addressed.
Academic Editors: Tipu Aziz and Alex Green
Received: 30 June 2016 / Revised: 13 August 2016 / Accepted: 15 August 2016 / Published: 19 August 2016
(This article belongs to the Special Issue Deep Brain Stimulation (DBS) Applications)
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Tourette syndrome (TS) is a childhood neurobehavioural disorder, characterised by the presence of motor and vocal tics, typically starting in childhood but persisting in around 20% of patients into adulthood. In those patients who do not respond to pharmacological or behavioural therapy, deep brain stimulation (DBS) may be a suitable option for potential symptom improvement. This manuscript attempts to summarise the outcomes of DBS at different targets, explore the possible mechanisms of action of DBS in TS, as well as the potential of adaptive DBS. There will also be a focus on the future challenges faced in designing optimized trials. View Full-Text
Keywords: Tourette syndrome; TS deep brain stimulation; DBS Tourette syndrome; TS deep brain stimulation; DBS

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Akbarian-Tefaghi, L.; Zrinzo, L.; Foltynie, T. The Use of Deep Brain Stimulation in Tourette Syndrome. Brain Sci. 2016, 6, 35.

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