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Open AccessArticle

Evidence of fNIRS-Based Prefrontal Cortex Hypoactivity in Obesity and Binge-Eating Disorder

1
Integrated Research and Treatment Center Adiposity Diseases, Behavioural Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig Medical Center, Semmelweisstrasse 10, 04103 Leipzig, Germany
2
International Max Planck Research School NeuroCom, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany
3
Brain Innovation B.V., Oxfordlaan 55, 6229 EV Maastricht, The Netherlands
4
Faculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Oxfordlaan 55, 6229 EV Maastricht, The Netherlands
5
Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstrasse 14, 72076 Tübingen, Germany
6
Department of Nuclear Medicine, University of Leipzig Medical Center, Liebigstrasse 18, 04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Brain Sci. 2021, 11(1), 19; https://doi.org/10.3390/brainsci11010019
Received: 1 December 2020 / Revised: 16 December 2020 / Accepted: 22 December 2020 / Published: 26 December 2020
Obesity (OB) and associated binge-eating disorder (BED) show increased impulsivity and emotional dysregulation. Albeit well-established in neuropsychiatric research, functional near-infrared spectroscopy (fNIRS) has rarely been used to study OB and BED. Here, we investigated fNIRS-based food-specific brain signalling, its association with impulsivity and emotional dysregulation, and the temporal variability in individuals with OB with and without BED compared to an age- and sex-stratified normal weight (NW) group. Prefrontal cortex (PFC) responses were recorded in individuals with OB (n = 15), OB + BED (n = 13), and NW (n = 12) in a passive viewing and a response inhibition task. Impulsivity and emotional dysregulation were self-reported; anthropometrics were objectively measured. The OB and NW groups were measured twice 7 days apart. Relative to the NW group, the OB and OB + BED groups showed PFC hyporesponsivity across tasks, whereas there were few significant differences between the OB and OB + BED groups. Greater levels of impulsivity were significantly associated with stronger PFC responses, while more emotional dysregulation was significantly associated with lower PFC responses. Temporal differences were found in the left orbitofrontal cortex responses, yet in opposite directions in the OB and NW groups. This study demonstrated diminished fNIRS-based PFC responses across OB phenotypes relative to a NW group. The association between impulsivity, emotional dysregulation, and PFC hypoactivity supports the assumption that BED constitutes a specific OB phenotype. View Full-Text
Keywords: obesity; binge-eating disorder; fNIRS; emotional dysregulation; prefrontal cortex; impulsivity obesity; binge-eating disorder; fNIRS; emotional dysregulation; prefrontal cortex; impulsivity
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MDPI and ACS Style

Rösch, S.A.; Schmidt, R.; Lührs, M.; Ehlis, A.-C.; Hesse, S.; Hilbert, A. Evidence of fNIRS-Based Prefrontal Cortex Hypoactivity in Obesity and Binge-Eating Disorder. Brain Sci. 2021, 11, 19. https://doi.org/10.3390/brainsci11010019

AMA Style

Rösch SA, Schmidt R, Lührs M, Ehlis A-C, Hesse S, Hilbert A. Evidence of fNIRS-Based Prefrontal Cortex Hypoactivity in Obesity and Binge-Eating Disorder. Brain Sciences. 2021; 11(1):19. https://doi.org/10.3390/brainsci11010019

Chicago/Turabian Style

Rösch, Sarah A.; Schmidt, Ricarda; Lührs, Michael; Ehlis, Ann-Christine; Hesse, Swen; Hilbert, Anja. 2021. "Evidence of fNIRS-Based Prefrontal Cortex Hypoactivity in Obesity and Binge-Eating Disorder" Brain Sci. 11, no. 1: 19. https://doi.org/10.3390/brainsci11010019

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