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Open AccessArticle

PRGF-Modified Collagen Membranes for Guided Bone Regeneration: Spectroscopic, Microscopic and Nano-Mechanical Investigations

1
Faculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410081 Oradea, Romania
2
Advanced Materials Research Laboratory, University of Oradea, 1 Universității Street, 410087 Oradea, Romania
3
Faculty of Electrical Engineering and Information Technology, University of Oradea, 1 University St., 410087 Oradea, Romania
*
Author to whom correspondence should be addressed.
Authors with equal contribution.
Appl. Sci. 2019, 9(5), 1035; https://doi.org/10.3390/app9051035
Received: 6 February 2019 / Revised: 4 March 2019 / Accepted: 8 March 2019 / Published: 12 March 2019
(This article belongs to the Special Issue Development of Membranes for Oral and Maxillofacial Application)
The aim of our study was to evaluate the properties of different commercially available resorbable collagen membranes for guided bone regeneration, upon addition of plasma rich in growth factors (PRGF). The structural and morphological details, mechanical properties, and enzymatic degradation were investigated in a new approach, providing clinicians with new data in order to help them in a successful comparison and better selection of membranes with respect to their placement and working condition. Particular characteristics such as porosity, fiber density, and surface topography may influence the mechanical behavior and performances of the membranes, as revealed by SEM/AFM and nanoindentation measurements. The mechanical properties and enzymatic degradation of the membranes were analyzed in a comparative manner, before and after PRGF-modification. The changes in Young modulus values are correlated with the ultrastructural properties of each membrane type. The enzymatic (trypsin) degradation test also emphasized that PRGF-modified membranes exhibit a slower degradation compared to the native ones. View Full-Text
Keywords: collagen; guided bone regeneration; membrane; nanoindentation collagen; guided bone regeneration; membrane; nanoindentation
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MDPI and ACS Style

Ratiu, C.; Brocks, M.; Costea, T.; Moldovan, L.; Cavalu, S. PRGF-Modified Collagen Membranes for Guided Bone Regeneration: Spectroscopic, Microscopic and Nano-Mechanical Investigations. Appl. Sci. 2019, 9, 1035. https://doi.org/10.3390/app9051035

AMA Style

Ratiu C, Brocks M, Costea T, Moldovan L, Cavalu S. PRGF-Modified Collagen Membranes for Guided Bone Regeneration: Spectroscopic, Microscopic and Nano-Mechanical Investigations. Applied Sciences. 2019; 9(5):1035. https://doi.org/10.3390/app9051035

Chicago/Turabian Style

Ratiu, Cristian; Brocks, Marcel; Costea, Traian; Moldovan, Liviu; Cavalu, Simona. 2019. "PRGF-Modified Collagen Membranes for Guided Bone Regeneration: Spectroscopic, Microscopic and Nano-Mechanical Investigations" Appl. Sci. 9, no. 5: 1035. https://doi.org/10.3390/app9051035

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