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Open AccessReview

Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation

1
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran
2
Department of Food Science, Faculty of Food Engineering (FEA), University of Campinas (UNICAMP), Campinas, 13083-862 Sao Paulo, Brazil
3
Department of Pharmaceutical Sciences, Bhimtal Campus, Kumaun University, Nainital 263136, Uttarakhand, India
4
G.B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi Katarmal, Almora 263643, India
5
Research Institution “Chinese-Tajik Innovation Center for Natural Products”, Academy of Sciences of the Republic of Tajikistan, Ayni 299/2, Dushanbe 734063, Tajikistan
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Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China
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Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
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Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
9
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2019, 9(24), 5555; https://doi.org/10.3390/app9245555
Received: 1 November 2019 / Revised: 29 November 2019 / Accepted: 5 December 2019 / Published: 17 December 2019
Garlic has been used for a long time in human history. Allicin, the main active compound present in freshly injured garlic, is enzymatically formed from alliin. Allicin has shown doubtless beneficial effects and even be conceived as medicine. The present review highlights allicin-associated studies. Indeed, clinical studies on healthy subjects have evidenced that standardized garlic treatment (900 mg/day) significantly reduces total cholesterol (TC) and low-density lipoprotein cholesterol (c-LDL). Besides, allicin also led to a marked improvement in mouth opening, burning sensation, and oral health-related quality of life on stage II oral submucous fibrosis patients. Interestingly, in children, allicin also has been proposed for thrush prevention and as an alternative antibiotic therapy. Nonetheless, there is particular attention to allicin bioavailability, given its high instability. Although clinical evidence has promoted allicin release from garlic powder tablets under simulated gastrointestinal conditions, garlic tablets are those that have provided less alliinase protection due to its fast disintegration, releasing low allicin amounts. View Full-Text
Keywords: Allium sativum L.; allicin; garlic preparations; cholesterol Allium sativum L.; allicin; garlic preparations; cholesterol
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MDPI and ACS Style

Sharifi-Rad, J.; Cristina Cirone Silva, N.; Jantwal, A.; D. Bhatt, I.; Sharopov, F.; C. Cho, W.; Taheri, Y.; Martins, N. Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation. Appl. Sci. 2019, 9, 5555.

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