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Review

Polymeric Nanoparticles—Tools in a Drug Delivery System in Selected Cancer Therapies

by
Marcel Madej
,
Natalia Kurowska
and
Barbara Strzalka-Mrozik
*
Department of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland
*
Author to whom correspondence should be addressed.
Appl. Sci. 2022, 12(19), 9479; https://doi.org/10.3390/app12199479
Submission received: 16 August 2022 / Revised: 15 September 2022 / Accepted: 17 September 2022 / Published: 21 September 2022
(This article belongs to the Special Issue Advances in Biomaterials and Drug Technology)

Abstract

The increase in cancer cases is undoubtedly affecting the development of new therapeutic approaches. Polymeric nanoparticles are of great interest. Due to their relatively small size, the possibility of incorporating into them medicinal substances and the ease with which their physicochemical properties may be manipulated, they are being used as anticancer drug delivery systems. The aim of this review is to focus on the use of nanoscale polymeric particles in the treatment of colorectal cancer, breast cancer, ovarian cancer and glioblastoma multiforme, and to consider their potential use in cancer gene therapy. According to several reports, the use of polymer nanoparticles as drug carriers is promising in solid tumors. With their application, it is possible to precisely deliver medicinal substances to the tumor structure, to overcome the blood–brain barrier in the case of brain tumors, to reduce the side effects of anticancer agents on normal cells and to achieve a therapeutic effect with a lower drug dose. Additionally, a number of reports indicate that they can also be used in combination with other methods of cancer treatment, mainly radiotherapy.
Keywords: nanoparticles; nanospheres; nanoformulation; polymer; drug delivery system; breast cancer; colorectal cancer; ovarian cancer; glioblastoma multiforme; double emulsion nanoparticles; nanospheres; nanoformulation; polymer; drug delivery system; breast cancer; colorectal cancer; ovarian cancer; glioblastoma multiforme; double emulsion

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MDPI and ACS Style

Madej, M.; Kurowska, N.; Strzalka-Mrozik, B. Polymeric Nanoparticles—Tools in a Drug Delivery System in Selected Cancer Therapies. Appl. Sci. 2022, 12, 9479. https://doi.org/10.3390/app12199479

AMA Style

Madej M, Kurowska N, Strzalka-Mrozik B. Polymeric Nanoparticles—Tools in a Drug Delivery System in Selected Cancer Therapies. Applied Sciences. 2022; 12(19):9479. https://doi.org/10.3390/app12199479

Chicago/Turabian Style

Madej, Marcel, Natalia Kurowska, and Barbara Strzalka-Mrozik. 2022. "Polymeric Nanoparticles—Tools in a Drug Delivery System in Selected Cancer Therapies" Applied Sciences 12, no. 19: 9479. https://doi.org/10.3390/app12199479

APA Style

Madej, M., Kurowska, N., & Strzalka-Mrozik, B. (2022). Polymeric Nanoparticles—Tools in a Drug Delivery System in Selected Cancer Therapies. Applied Sciences, 12(19), 9479. https://doi.org/10.3390/app12199479

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