Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Peritoneal Dialytic Effluent: Preliminary Results on the Comparison between Two Different Methods in Patients with and without Peritonitis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. NGAL Measurements
2.3. Endpoints
2.4. Statistical Analysis
3. Results
3.1. Subjects Baseline Characteristics
3.2. Laboratory Parameters Evaluation
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Baseline Characteristics | Case Group (N 17) | Control Group (N 13) | p-Value |
---|---|---|---|
Age, year, median (IQR) | 73 (55−80) | 56 (55−72) | 0.34 a |
Dialysis vintage, mean ± SD | 49 (17−49) | 17 (11−49) | 0.14 a |
Gender, men, number (%) | 13 (73) | 7 (53) | 0.2 b |
BMI, mean ± SD | 23.6 ± 4.8 | 26.9 ± 6.2 | 0.13 c |
Hemoglobin, g/L, mean ± SD | 109 ± 24.8 | 113 ± 14.8 | 0.69 c |
Total Weekly Kt/Vurea, median (IQR) | 1.8 (1.6−1.9) | 1.7 (1.6−1.9) | 0.81 a |
Total wCCr, median (IQR) | 53.5 (45.5−70.6) | 55 (45.7−66.8) | 0.91 a |
Gram Stain | Causative Organism of Peritonitis | Percentage (%) |
---|---|---|
Gram-positive (65%) | Coagulase-negative Staphylococci | 12 |
Staphylococcus aureus | 29 | |
Streptococcus species | 18 | |
Enterococcus | 6 | |
Gram-negative (24%) | Acinetobacter | 6 |
Pseudomonas | 18 | |
Sterile (11%) | 11 |
Case Group | Control Group | p | |
---|---|---|---|
CRP mg/dL, median (IQR) | 5.8 (3.2−12.3) | 1.6 (1.2−2.5) | 0.01 a |
WBC count in blood (109/L), median (IQR) | 7.6 (5.9−10.7) | 5.5 (5.1−6.1) | 0.03 a |
White cell count in PDE (106/L), median (IQR) | 2.8 (0.5−4.7) | 0.7 (0.5−8.6) | 0.01 a |
Peritoneal laboratory-based NGAL test (ng/mL), median (IQR) | 265 (198−517) | 80 (46−121) | 0.01 a |
Peritoneal NGALds (ng/mL), median (IQR) | 300 (300−600) | 100 (50−150) | <0.01 a |
ISPD Peritonitis | |
---|---|
Peritoneal NGALds | No. of patients |
600 ng/mL | 7 |
300 ng/mL | 10 |
150 ng/mL | 0 |
100 ng/mL | 0 |
50 ng/mL | 0 |
25 ng/mL | 0 |
No Peritonitis | |
Peritoneal NGALds | No. of patients |
600 ng/mL | 0 |
300 ng/mL | 2 |
150 ng/mL | 4 |
100 ng/mL | 3 |
50 ng/mL | 1 |
25 ng/mL | 3 |
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Virzì, G.M.; Milan Manani, S.; Marcello, M.; Costa, E.; Marturano, D.; Tantillo, I.; Lerco, S.; Corradi, V.; De Cal, M.; Martino, F.K.; et al. Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Peritoneal Dialytic Effluent: Preliminary Results on the Comparison between Two Different Methods in Patients with and without Peritonitis. Appl. Sci. 2022, 12, 5092. https://doi.org/10.3390/app12105092
Virzì GM, Milan Manani S, Marcello M, Costa E, Marturano D, Tantillo I, Lerco S, Corradi V, De Cal M, Martino FK, et al. Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Peritoneal Dialytic Effluent: Preliminary Results on the Comparison between Two Different Methods in Patients with and without Peritonitis. Applied Sciences. 2022; 12(10):5092. https://doi.org/10.3390/app12105092
Chicago/Turabian StyleVirzì, Grazia Maria, Sabrina Milan Manani, Matteo Marcello, Elisa Costa, Davide Marturano, Ilaria Tantillo, Silvia Lerco, Valentina Corradi, Massimo De Cal, Francesca K. Martino, and et al. 2022. "Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Peritoneal Dialytic Effluent: Preliminary Results on the Comparison between Two Different Methods in Patients with and without Peritonitis" Applied Sciences 12, no. 10: 5092. https://doi.org/10.3390/app12105092
APA StyleVirzì, G. M., Milan Manani, S., Marcello, M., Costa, E., Marturano, D., Tantillo, I., Lerco, S., Corradi, V., De Cal, M., Martino, F. K., Giuliani, A., Carta, M., Giavarina, D., Ronco, C., & Zanella, M. (2022). Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Peritoneal Dialytic Effluent: Preliminary Results on the Comparison between Two Different Methods in Patients with and without Peritonitis. Applied Sciences, 12(10), 5092. https://doi.org/10.3390/app12105092