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In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation

Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, nam. Sitna 3105, CZ-272 01 Kladno, Czech Republic
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Appl. Sci. 2021, 11(3), 899; https://doi.org/10.3390/app11030899
Received: 11 December 2020 / Revised: 12 January 2021 / Accepted: 15 January 2021 / Published: 20 January 2021
(This article belongs to the Section Applied Biosciences and Bioengineering)
High-frequency oscillatory ventilation (HFOV), which uses a small tidal volume and a high respiratory rate, is considered a type of protective lung ventilation that can be beneficial for certain patients. A disadvantage of HFOV is its limited monitoring of lung mechanics, which complicates its settings and optimal adjustment. Recent studies have shown that respiratory system reactance (Xrs) could be a promising parameter in the evaluation of respiratory system mechanics in HFOV. The aim of this study was to verify in vitro that a change in respiratory system mechanics during HFOV can be monitored by evaluating Xrs. We built an experimental system consisting of a 3100B high-frequency oscillatory ventilator, a physical model of the respiratory system with constant compliance, and a system for pressure and flow measurements. During the experiment, models of different constant compliance were connected to HFOV, and Xrs was derived from the impedance of the physical model that was calculated from the spectral density of airway opening pressure and spectral cross-power density of gas flow and airway opening pressure. The calculated Xrs changed with the change of compliance of the physical model of the respiratory system. This method enabled monitoring of the trend in the respiratory system compliance during HFOV, and has the potential to optimize the mean pressure setting in HFOV in clinical practice. View Full-Text
Keywords: high-frequency oscillatory ventilation; continuous distending pressure; lung compliance; respiratory system reactance; rigid respiratory system model high-frequency oscillatory ventilation; continuous distending pressure; lung compliance; respiratory system reactance; rigid respiratory system model
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MDPI and ACS Style

Matejka, J.; Rozanek, M.; Rafl, J.; Kudrna, P.; Roubik, K. In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation. Appl. Sci. 2021, 11, 899. https://doi.org/10.3390/app11030899

AMA Style

Matejka J, Rozanek M, Rafl J, Kudrna P, Roubik K. In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation. Applied Sciences. 2021; 11(3):899. https://doi.org/10.3390/app11030899

Chicago/Turabian Style

Matejka, Jan; Rozanek, Martin; Rafl, Jakub; Kudrna, Petr; Roubik, Karel. 2021. "In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation" Appl. Sci. 11, no. 3: 899. https://doi.org/10.3390/app11030899

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