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Article

Hydroxyl Radical Generation by the H2O2/CuII/Phenanthroline System under Both Neutral and Alkaline Conditions: An EPR/Spin-Trapping Investigation

1
Institute of Engineering, University Grenoble Alpes, CNRS, Grenoble INP, LGP2, F-38000 Grenoble, France
2
Department of Molecular Chemistry, University Grenoble Alpes, CNRS, DCM, F-38000 Grenoble, France
*
Author to whom correspondence should be addressed.
Appl. Sci. 2021, 11(2), 687; https://doi.org/10.3390/app11020687
Received: 1 December 2020 / Revised: 8 January 2021 / Accepted: 10 January 2021 / Published: 12 January 2021
The copper–phenanthroline complex CuI(Phen)2 was the first artificial nuclease studied in biology. The mechanism responsible for this activity involves CuII(Phen)2 and H2O2. Even if H2O2/Cu systems have been extensively studied in biology and oxidative chemistry, most of these studies were carried out at physiological pH only, and little information is available on the generation of radicals by the H2O2/CuII-Phen system. In the context of paper pulp bleaching to improve the bleaching ability of H2O2, this system has been investigated, mostly at alkaline pH, and more recently at near-neutral pH in the case of dyed cellulosic fibers. Hence, this paper aims at studying the production of radicals with the H2O2/CuII-Phen system at near-neutral and alkaline pHs. Using the EPR/spin-trapping method, HO formation was monitored to understand the mechanisms involved. DMPO was used as a spin-trap to form DMPO–OH in the presence of HO, and two HO scavengers were compared to identify the origin of the observed DMPO–OH adduct, as nucleophilic addition of water onto DMPO leads to the same adduct. H2O2 decomposition was enhanced by the addition of CuII–Phen (and only slightly by addition of CuSO4), reaching a level similar to the Fenton reagent at near-neutral pH. This evidences the role of Phen, which improves the effect of CuII by tuning the electronic structure and structural properties of the corresponding CuII complexes. View Full-Text
Keywords: copper-phenanthroline complex; EPR spectroscopy; hydrogen peroxide; hydroxyl radical; spin-trapping copper-phenanthroline complex; EPR spectroscopy; hydrogen peroxide; hydroxyl radical; spin-trapping
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MDPI and ACS Style

Walger, E.; Marlin, N.; Mortha, G.; Molton, F.; Duboc, C. Hydroxyl Radical Generation by the H2O2/CuII/Phenanthroline System under Both Neutral and Alkaline Conditions: An EPR/Spin-Trapping Investigation. Appl. Sci. 2021, 11, 687. https://doi.org/10.3390/app11020687

AMA Style

Walger E, Marlin N, Mortha G, Molton F, Duboc C. Hydroxyl Radical Generation by the H2O2/CuII/Phenanthroline System under Both Neutral and Alkaline Conditions: An EPR/Spin-Trapping Investigation. Applied Sciences. 2021; 11(2):687. https://doi.org/10.3390/app11020687

Chicago/Turabian Style

Walger, Elsa, Nathalie Marlin, Gérard Mortha, Florian Molton, and Carole Duboc. 2021. "Hydroxyl Radical Generation by the H2O2/CuII/Phenanthroline System under Both Neutral and Alkaline Conditions: An EPR/Spin-Trapping Investigation" Applied Sciences 11, no. 2: 687. https://doi.org/10.3390/app11020687

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