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Open AccessFeature PaperReview

Update on TB Vaccine Pipeline

1
Grupo de Genética de Micobacterias, Microbiología, Facultad de Medicina Universidad de Zaragoza, 50009 Zaragoza, Spain
2
CIBERES Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain
3
Servicio de Microbiología, Hospital Universitario Miguel Servet, 3ISS Aragón, 50009 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(7), 2632; https://doi.org/10.3390/app10072632
Received: 10 March 2020 / Revised: 30 March 2020 / Accepted: 31 March 2020 / Published: 10 April 2020
(This article belongs to the Special Issue Tuberculosis Drug Discovery and Development 2019)
In addition to antibiotics, vaccination is considered among the most efficacious methods in the control and the potential eradication of infectious diseases. New safe and effective vaccines against tuberculosis (TB) could be a very important tool and are called to play a significant role in the fight against TB resistant to antimicrobials. Despite the extended use of the current TB vaccine Bacillus Calmette-Guérin (BCG), TB continues to be transmitted actively and continues to be one of the 10 most important causes of death in the world. In the last 20 years, different TB vaccines have entered clinical trials. In this paper, we review the current use of BCG and the diversity of vaccines in clinical trials and their possible indications. New TB vaccines capable of protecting against respiratory forms of the disease caused by sensitive or resistant Mycobacterium tuberculosis strains would be extremely useful tools helping to prevent the emergence of multi-drug resistance. View Full-Text
Keywords: BCG; tuberculosis vaccines; TBVI; EDCTP; IAVI; CTVD BCG; tuberculosis vaccines; TBVI; EDCTP; IAVI; CTVD
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MDPI and ACS Style

Martin, C.; Aguilo, N.; Marinova, D.; Gonzalo-Asensio, J. Update on TB Vaccine Pipeline. Appl. Sci. 2020, 10, 2632. https://doi.org/10.3390/app10072632

AMA Style

Martin C, Aguilo N, Marinova D, Gonzalo-Asensio J. Update on TB Vaccine Pipeline. Applied Sciences. 2020; 10(7):2632. https://doi.org/10.3390/app10072632

Chicago/Turabian Style

Martin, Carlos; Aguilo, Nacho; Marinova, Dessislava; Gonzalo-Asensio, Jesus. 2020. "Update on TB Vaccine Pipeline" Appl. Sci. 10, no. 7: 2632. https://doi.org/10.3390/app10072632

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