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Article

Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study

1
Global Health Technology Research Center, Korea University, Seoul 02841, Korea
2
Clinical Trial Center, Dunsan Korean Medicine Hospital, Daejeon 34323, Korea
3
Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
4
Division of Intelligent Robot, DGIST, Daegu 42988, Korea
5
Department of Sports Medicine, Konyang University, Chungnam 32992, Korea
6
Department of Neurology Disorders, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon 35235, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Appl. Sci. 2020, 10(24), 8954; https://doi.org/10.3390/app10248954
Received: 18 November 2020 / Revised: 10 December 2020 / Accepted: 14 December 2020 / Published: 15 December 2020
(This article belongs to the Section Applied Biosciences and Bioengineering)
Acupuncture is increasingly being used as an alternative treatment for patients with Parkinson’s disease (PD). We aimed to evaluate the effects of acupuncture on gait-related brain function in patients with PD using functional near-infrared spectroscopy (fNIRS). Twenty-four patients with PD were randomly assigned to intervention (acupuncture twice a week for 4 weeks) or control (non-treatment) groups. fNIRS experiments applying a block design were performed at baseline (0 weeks) and 4- and 8-week follow-up and cortical activation and connectivity were evaluated. After acupuncture treatment, oxy-hemoglobin (HbO) levels in the intervention group were significantly increased in the primary motor cortex (M1), supplementary motor area (SMA), and prefrontal cortex (PFC). Furthermore, following acupuncture treatment in the intervention group, the connectivities in the M1 and PFC regions increased. The results show that acupuncture may be a useful complementary treatment for gait disturbances in patients with PD, and fNIRS can be applicable to evaluate neural plasticity directly. The evaluation method in this paper can be used to assess the neural plasticity related to various rehabilitation techniques. View Full-Text
Keywords: functional near-infrared spectroscopy; acupuncture; Parkinson’s disease; brain connectivity functional near-infrared spectroscopy; acupuncture; Parkinson’s disease; brain connectivity
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MDPI and ACS Style

Lee, S.H.; Park, S.-S.; Jang, J.-h.; Jin, S.H.; Baik, Y.-S.; Yoo, H.-R. Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study. Appl. Sci. 2020, 10, 8954. https://doi.org/10.3390/app10248954

AMA Style

Lee SH, Park S-S, Jang J-h, Jin SH, Baik Y-S, Yoo H-R. Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study. Applied Sciences. 2020; 10(24):8954. https://doi.org/10.3390/app10248954

Chicago/Turabian Style

Lee, Seung H., Sang-Soo Park, Jung-hee Jang, Sang H. Jin, Young-Soo Baik, and Ho-Ryong Yoo. 2020. "Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study" Applied Sciences 10, no. 24: 8954. https://doi.org/10.3390/app10248954

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