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Microbiota Alterations in Gastrointestinal Cancers

Department of Medical Biochemistry, Medical University of Lodz, 90-419 Lodz, Poland
Department of Food Sciences, Medical University of Lodz, 90-419 Lodz, Poland
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(2), 585;
Received: 6 November 2019 / Revised: 23 December 2019 / Accepted: 6 January 2020 / Published: 13 January 2020
(This article belongs to the Section Applied Biosciences and Bioengineering)
Commensal microbiota plays a critical role in the maintenance of human health. Microbes influence energy metabolism and nutrient absorption and help defend the host organism against pathogens. The composition of the gut microbiota is delicately balanced, and any alterations may lead to proinflammatory immune responses and initiation of disease processes, including cancer. Experimental evidence indicates that the human intestinal microbiota can influence tumour development and progression in the gastrointestinal tract by damaging DNA, activation of oncogenic signaling pathways, production of tumour-promoting metabolites, and suppression of the anti-tumour immune response. The aim of this article was to outline differences in human microbiota between healthy subjects and patients with gastrointestinal malignancies such as esophageal, stomach, liver, biliary tract, pancreas and colon inflammations, and cancers. A better understanding of microbiota changes in various gastrointestinal malignancies will enable a greater insight into the relationship between human microbiota composition and cancer development. View Full-Text
Keywords: cancer; gastrointestinal cancer; microbiota cancer; gastrointestinal cancer; microbiota
MDPI and ACS Style

Karwowska, Z.; Szemraj, J.; Karwowski, B. Microbiota Alterations in Gastrointestinal Cancers. Appl. Sci. 2020, 10, 585.

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