Table of Contents
Med. Sci., Volume 8, Issue 2 (June 2020) – 6 articles
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Cover Story (view full-size image) Cardiac remodeling requires the ability of cardiomyocytes to adapt to an alterations in [...] Read more. Cardiac remodeling requires the ability of cardiomyocytes to adapt to an alterations in three-dimensional structure of the heart. This complex scenario can be studied ex vivo by challenging isolated ventricular cardiomyocytes to adapt to a two-dimensional cell culture dish. Using this approach, it was shown that growth factors can induce the expression of proteasome subunit low molecular weight protein (LMP)-2 . Obviously, this accelerates proteasomal degradation of sarcomere proteins, allowing the cells to rearrange their sarcomeres as required for adaptation to altered environments. Without this induction, cells are unable to de-arrange their existing sarcomeres and subsequently unable to rebuild new sarcomeres as required for successful survival.