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Med. Sci., Volume 7, Issue 9 (September 2019)
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Cover Story (view full-size image) Kappa-opioid agonists (KOAs) enhance cardiac performance and reduce infarct size and prevent [...] Read more. Kappa-opioid agonists (KOAs) enhance cardiac performance and reduce infarct size and prevent deleterious cardiac remodeling following myocardial infarction. Additionally, KOAs promote diuresis; however, there has been limited development of KOAs as a class due to the promotion of untoward central nervous system (CNS)-mediated side effects. The Dix lab has developed a peripherally-restricted, orally-active, KOA (
JT09) for the treatment of pain and cardiovascular disease. Peripherally-restricted KOAs have a limited side-effect profile and demonstrate potential in preventing heart failure. In this study, we establish a preliminary diuretic profile for lead compound JT09 following single oral administration to adult male Sprague Dawley rats. View this paper.