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Medical Sciences, Volume 7, Issue 9

2019 September - 9 articles

Cover Story: Kappa-opioid agonists (KOAs) enhance cardiac performance and reduce infarct size and prevent deleterious cardiac remodeling following myocardial infarction. Additionally, KOAs promote diuresis; however, there has been limited development of KOAs as a class due to the promotion of untoward central nervous system (CNS)-mediated side effects. The Dix lab has developed a peripherally-restricted, orally-active, KOA (JT09) for the treatment of pain and cardiovascular disease. Peripherally-restricted KOAs have a limited side-effect profile and demonstrate potential in preventing heart failure. In this study, we establish a preliminary diuretic profile for lead compound JT09 following single oral administration to adult male Sprague Dawley rats. View this paper.
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Articles (9)

  • Review
  • Open Access
13 Citations
12,478 Views
16 Pages

18 September 2019

Peyronie’s disease is a condition that causes abnormal healing of the tunica albuginea, causing penile curvature. It is difficult to treat and its management is continuing to evolve. Proposed non-surgical treatments have included oral, topical,...

  • Review
  • Open Access
38 Citations
8,690 Views
10 Pages

A Review of First Line Infertility Treatments and Supporting Evidence in Women with Polycystic Ovary Syndrome

  • Michael Costello,
  • Rhonda Garad,
  • Roger Hart,
  • Hayden Homer,
  • Louise Johnson,
  • Cailin Jordan,
  • Edgar Mocanu,
  • Jie Qiao,
  • Luk Rombauts and
  • William Ledger
  • + 3 authors

10 September 2019

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age. Lifestyle change is considered the first line treatment for the management of infertile anovulatory women with PCOS, and weight loss fo...

  • Article
  • Open Access
1 Citations
2,869 Views
9 Pages

8 September 2019

Intra-abdominal infections (IAI) are associated with high levels of pro-inflammatory serum IL-8 and poor outcomes, but data on IL-8 levels in various inflammatory reactions are contradictory. A better understanding of the diagnostic role of IL-8 is i...

  • Article
  • Open Access
4 Citations
3,430 Views
12 Pages

Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist

  • Tyler C. Beck,
  • Matthew A. Hapstack,
  • Gautam S. Ghatnekar and
  • Thomas A. Dix

31 August 2019

Kappa-opioid agonists (KOAs) enhance cardiac performance, as well as reduce infarct size and prevent deleterious cardiac remodeling following myocardial infarction. Additionally, KOAs promote diuresis; however, there has been limited development of K...

  • Perspective
  • Open Access
23 Citations
4,950 Views
9 Pages

30 August 2019

Objectives: to evaluate incidence and prevalence rates of polymyalgia rheumatica (PMR) in Italy, depending on the epidemiological methodology used from time to time. Materials and Methods: A comprehensive literature search in MEDLINE and EMBASE was c...

  • Review
  • Open Access
2 Citations
6,690 Views
12 Pages

Erectile Dysfunction: A Primer for in Office Management

  • Samir Sami,
  • Noah Stern,
  • Andrew Di Pierdomenico,
  • Brandon Katz and
  • Gerald Brock

29 August 2019

Introduction: Optimizing erectile dysfunction (ED) remains a clinically significant endeavor as insufficient outcomes from oral, injectable and even surgical approaches to treatment remain less than ideal. In this report, we integrate evolving knowle...

  • Review
  • Open Access
25 Citations
13,743 Views
11 Pages

29 August 2019

Contemporary treatment algorithms for erectile dysfunction (ED) involve the use of medical therapies such as phosphodiesterase type 5 (PDE5) inhibitors and intracavernosal injection therapy of vasoactive agents, as well as vacuum erection devices and...

  • Review
  • Open Access
111 Citations
24,213 Views
12 Pages

The Mechanism of Androgen Actions in PCOS Etiology

  • Valentina Rodriguez Paris and
  • Michael J. Bertoldo

28 August 2019

Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-age women. By comprising reproductive, endocrine, metabolic and psychological features—the cause of PCOS is still unknown. Consequently, there is no cure, a...

  • Article
  • Open Access
2 Citations
12,320 Views
6 Pages

22 August 2019

Ascites, the fluid accumulation in the peritoneal cavity, is most commonly seen in patients with end-stage liver disease (ESLD). Evaluating ascites or providing symptomatic relief for patients is accomplished by performing a paracentesis. Ascites lea...

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Med. Sci. - ISSN 2076-3271