Table of Contents
Med. Sci., Volume 7, Issue 4 (April 2019)
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Cover Story (view full-size image) This systematic review indicates that creatine kinase (CK), the main human phosphagen kinase, is [...] Read more. This systematic review indicates that creatine kinase (CK), the main human phosphagen kinase, is associated with blood pressure. CK rapidly regenerates ATP near ATPases involved in pressor responses, including calcium-ATPase and mysosin-ATPase for cardiovascular contractility, and sodium/potassium-ATPase for sodium retention. We systematically reviewed data from 34,578 African, Asian, and European ancestry persons aged 18-87 years. The adjusted increase in systolic blood pressure (mmHg/log CK increase) was between 3.3[95% CI, 1.4 to 5.2] and 8.0[3.3 to 12.7]. The odds ratio for hypertension ranged between 1.2 and 3.9, and treatment failed more frequently in participants with high (vs low) CK (odds ratio 3.7[1.2 to 10.9]. Further work needs to address the clinical usefulness of this new cardiovascular risk factor. View this paper