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Medical Sciences, Volume 7, Issue 4

April 2019 - 13 articles

Cover Story: This systematic review indicates that creatine kinase (CK), the main human phosphagen kinase, is associated with blood pressure. CK rapidly regenerates ATP near ATPases involved in pressor responses, including calcium-ATPase and mysosin-ATPase for cardiovascular contractility, and sodium/potassium-ATPase for sodium retention. We systematically reviewed data from 34,578 African, Asian, and European ancestry persons aged 18-87 years. The adjusted increase in systolic blood pressure (mmHg/log CK increase) was between 3.3[95% CI, 1.4 to 5.2] and 8.0[3.3 to 12.7]. The odds ratio for hypertension ranged between 1.2 and 3.9, and treatment failed more frequently in participants with high (vs low) CK (odds ratio 3.7[1.2 to 10.9]. Further work needs to address the clinical usefulness of this new cardiovascular risk factor. View this paper
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Articles (13)

  • Article
  • Open Access
5 Citations
3,946 Views
12 Pages

24 April 2019

Type 2 diabetes affects over 340 million people worldwide. This condition can go unnoticed and undiagnosed for years, leading to a late stage where high glycaemia produces complications such as delayed wound healing. Studies have shown that 12-HHT th...

  • Article
  • Open Access
5 Citations
11,094 Views
8 Pages

Ability of Vital and Fluorescent Staining in the Differentiation of Schistosoma haematobium Live and Dead Eggs

  • Peter O. Forson,
  • Patience B. Tetteh-Quarcoo,
  • John Ahenkorah,
  • Robert Aryee,
  • Esther N. Okine,
  • Emmanuel Afutu,
  • Georgina I. Djameh,
  • Jeffrey Agyapong,
  • Abraham K. Anang and
  • Patrick F. Ayeh-Kumi

23 April 2019

This study reports (for the first time) the staining ability of vital (0.4% trypan blue and 1% neutral red) and fluorescent (Hoechst 33258) dyes to differentiate between live and dead Schistosoma haematobium (S. haematobium) eggs in human urine sampl...

  • Article
  • Open Access
6 Citations
5,048 Views
18 Pages

The Keeping on Track Study: Exploring the Activity Levels and Utilization of Healthcare Services of Acute Coronary Syndrome (ACS) Patients in the First 30-Days after Discharge from Hospital

  • Robyn A. Clark,
  • Jonathon Foote,
  • Vincent L. Versace,
  • Alex Brown,
  • Mark Daniel,
  • Neil T. Coffee,
  • Tania S. Marin,
  • Constance Kourbelis,
  • Margaret Arstall and
  • Anand Ganesan
  • + 6 authors

19 April 2019

The aim of this study was to investigate the impact of bedside discharge education on activity levels and healthcare utilization for patients with acute coronary syndrome (ACS) in the first 30 days post-discharge. Knowledge recall and objective activ...

  • Article
  • Open Access
8 Citations
3,819 Views
8 Pages

TRPA1 Channel is Involved in SLIGRL-Evoked Thermal and Mechanical Hyperalgesia in Mice

  • Merab G. Tsagareli,
  • Ivliane Nozadze,
  • Nana Tsiklauri and
  • Gulnaz Gurtskaia

18 April 2019

Persistent itch (pruritus) accompanying dermatologic and systemic diseases can significantly impair the quality of life. It is well known that itch is broadly categorized as histaminergic (sensitive to antihistamine medications) or non-histaminergic....

  • Article
  • Open Access
13 Citations
4,173 Views
8 Pages

18 April 2019

The present study was performed to evaluate the clinical symptoms and cardiovascular complications in patients with typical and atypical Kawasaki disease (KD). This retrospective study was conducted on the medical records of 176 patients with KD for...

  • Article
  • Open Access
6 Citations
4,037 Views
14 Pages

12 April 2019

Lipoxygenase-derived lipid mediators can modulate inflammation and are stimulated in response to influenza infections. We report an effect of 8-lipoxygenase (ALOX8) on the recovery of mice after infection with Influenza virus X31. We compared the res...

  • Review
  • Open Access
31 Citations
8,755 Views
8 Pages

Developmental Dysplasia of Hip: Perspectives in Genetic Screening

  • Radoslav Zamborsky,
  • Milan Kokavec,
  • Stefan Harsanyi,
  • Doaa Attia and
  • Lubos Danisovic

11 April 2019

Development dysplasia of the hip (DDH) is a complex developmental disorder despite being a relatively common condition mainly caused by incompatibility of the femoral head and the abnormal joint socket. Development dysplasia of the hip describes a wi...

  • Review
  • Open Access
17 Citations
6,924 Views
12 Pages

Creatine Kinase and Blood Pressure: A Systematic Review

  • L. M. Brewster,
  • F. A. Karamat and
  • G. A. van Montfrans

Background: Hypertension is a main risk factor for premature death. Although blood pressure is a complex trait, we have shown that the activity of the ATP-generating enzyme creatine kinase (CK) is a significant predictor of blood pressure and of fail...

  • Review
  • Open Access
11 Citations
4,165 Views
6 Pages

Surgical Management of Chronic Rhinosinusitis in Cystic Fibrosis

  • Zhong Zheng,
  • Chetan Safi and
  • David A. Gudis

Cystic fibrosis patients frequently develop chronic rhinosinusitis as a result of their propensity to form inspissated mucus and impairment of mucociliary clearance. They exhibit variable symptom burden even in the setting of positive radiographic an...

  • Review
  • Open Access
140 Citations
58,472 Views
13 Pages

Magnesium is the fourth most abundant cation in the body and the second most abundant intracellular cation. It plays an important role in different organ systems at the cellular and enzymatic levels. Despite its importance, it still has not received...

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Med. Sci. - ISSN 2076-3271