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The Importance of Inhaler Adherence to Prevent COPD Exacerbations

by Jose R. Jardim 1,2,3,* and Oliver A. Nascimento 1,2,4,5
Respiratory Division, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/Unifesp), São Paulo 04023-062, Brazil
Pulmonary Rehabilitation Unit, EPM/Unifesp, São Paulo 04023-062, Brazil
Regional Medical Expert at GlaxoSmithKline (GSK), Rio de Janeiro 22783-110, Brazil
Faculdade de Medicina São Leopoldo Mandic/Instituto São Leopoldo Mandic, Campinas 13045-755, Brazil
Internal Medical Expert at GlaxoSmithKline (GSK), Rio de Janeiro 22783-110, Brazil
Author to whom correspondence should be addressed.
Med. Sci. 2019, 7(4), 54;
Received: 19 March 2019 / Accepted: 25 March 2019 / Published: 1 April 2019
(This article belongs to the Special Issue COPD Exacerbations)
It has been shown that the better outcomes of chronic obstructive pulmonary disease (COPD) are closely associated with adherence to drug therapy, independent of the treatment administered. The clinical trial Towards a Revolution in COPD Health (TORCH) study clearly showed in a three year follow up that patients with good adherence to their inhaler treatment presented a longer time before the first exacerbation, a lower susceptibility to exacerbation and lower all-cause mortality. The Latin American Study of 24-h Symptoms in Chronic Obstructive Pulmonary Disease (LASSYC), a real-life study, evaluated the self-reported inhaler adherence in COPD patients in seven countries in a cross-sectional non-interventional study and found that approximately 50% of the patients had good adherence, 30% moderate adherence and 20% poor adherence. Adherence to inhaler may be evaluated by the specific inhaler adherence questionnaire, the Test of Adherence to Inhalers (TAI). Several factors may predict the incorrect use of inhalers or adherence in COPD outpatient, including the number of devices and the daily dosing frequency. Ideally, patient education, simplicity of the device operation, the use of just one device for multiple medications and the best adaptation of the patient to the inhaler should guide the physician in prescribing the device. View Full-Text
Keywords: COPD; inhalers; bronchodilators; inhaled steroid; adherence COPD; inhalers; bronchodilators; inhaled steroid; adherence
MDPI and ACS Style

Jardim, J.R.; Nascimento, O.A. The Importance of Inhaler Adherence to Prevent COPD Exacerbations. Med. Sci. 2019, 7, 54.

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