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Repurposing Established Compounds to Target Pancreatic Cancer Stem Cells (CSCs)

Ludwig-Maximilians-University (LMU), Department of General, Visceral, and Transplantation Surgery, Hospital of the LMU Munich, Munich 81377, Germany
Ludwig-Maximilians-University (LMU), Department of Internal Medicine III, Hospital of the University of Munich, Munich 81377, Germany
Author to whom correspondence should be addressed.
Med. Sci. 2017, 5(2), 14;
Received: 19 April 2017 / Revised: 11 June 2017 / Accepted: 11 June 2017 / Published: 19 June 2017
(This article belongs to the Special Issue Gene Therapy and Cancer: Current Developments)
PDF [769 KB, uploaded 19 June 2017]
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The diagnosis of pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis, in particular, when patients present with unresectable disease. While significant progress has been made in understanding the biology of PDAC, this knowledge has not translated into a clear clinical benefit and current chemotherapeutic strategies only offer a modest improvement in overall survival. Accordingly, novel approaches are desperately needed. One hypothesis that could—at least in part—explain the desolate response of PDAC to chemotherapy is the so-called cancer stem cell (CSC) concept, which attributes specific traits, such as chemoresistance, metastatic potential and a distinct metabolism to a small cellular subpopulation of the whole tumor. At the same time, however, some of these attributes could make CSCs more permissive for novel therapeutic strategies with compounds that are already in clinical use. Most recently, several publications have tried to enlighten the field with the idea of repurposing established drugs for antineoplastic use. As such, recycling drugs could present an intriguing and fast-track method with new therapeutic paradigms in anti-cancer and anti-CSC treatments. Here, we aim to summarize important aspects and novel findings of this emerging field. View Full-Text
Keywords: pancreatic ductal adenocarcinoma; cancer stem cells; repurposing; therapeutics; metabolism pancreatic ductal adenocarcinoma; cancer stem cells; repurposing; therapeutics; metabolism

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Renz, B.W.; D’Haese, J.G.; Werner, J.; Westphalen, C.B.; Ilmer, M. Repurposing Established Compounds to Target Pancreatic Cancer Stem Cells (CSCs). Med. Sci. 2017, 5, 14.

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