A Systematic Review Exploring the Phytochemical Composition and Anticancer Activities of Acacia catechu
Abstract
1. Introduction
Methodology
2. Role of Phytoconstituents of A. catechu in Cancer
3. Cancer Pathways Modulated by A. catechu
3.1. Antiapoptotic Properties of A. catechu
3.2. Antioxidant Properties of A. catechu in Oncoprotection
3.3. Antiproliferative Activities
4. Safety Profile
5. Conclusions
6. Future Prospectives
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Plant Part | Phytoconstituents | Cancer Mechanisms | References |
---|---|---|---|
Heartwood | Catechin | ↓ Tumor growth, ↑ Antioxidant defense, ↓ c-jun levels | [18,19,20] |
Leaves | Catechin, Epicatechin, Epigallocatechin-3-O-gallate, Epicatechin-3-O-gallate. | Antiproliferative activity | [21,22] |
Cancer Type | Cell Line/Model | Plant Part | Concentration | Anticancer Effects | Mechanisms | References |
---|---|---|---|---|---|---|
Breast | MCF-7 | Stem bark | 7.8–1000 µg/mL | ↑ Cytotoxicity | Not reported | [31] |
Breast | MCF-7 | Heartwood | 1 ng–100 µg | ↓ Cell proliferation, ↑ Cell cycle arrest, ↑ Apoptosis | Not reported | [36] |
Colon | HT-29 | Heartwood | 0–1000 µg/mL | ↓ Cell viability, ↑ Cytotoxicity, ↑ Apoptosis | ↑ ROS, ↓ MMP, ↑ Caspase 3,9 | [27] |
Breast | MCF-7 | Bark | 50–250 µg/mL | DNA protection, Antiproliferative agent | - | [32] |
Skin | SCC-25 | Seeds | 0.1–1000 µg/mL | ↑ Cytotoxicity, ↑ Apoptosis | ↑ Caspase 8,9, cytochrome C, Bax, ↓ Bcl-2 | [26] |
Leukemia | K562 | - | 10–100 µg/mL | ↑ DNA damage, ↑ Cytotoxicity | ↑ G2/M arrest | [38] |
Breast | MCF-7/ Female Balb/c mice | Heartwood | 10–100 µg/mL 50 mg/kg | ↑ DNA fragmentation, ↑ Cell growth inhibition | ↓ p53, c-jun, NF-κB | [25] |
Breast | A431/ Balb/c mice | Heartwood | 10–100 µg/mL 400 mg/kg | ↓ Cell proliferation, visible necrotic keratinocytes, ↓ tumor burden | ↑ LDH ↑ LPO, CAT, ↓ SOD, GSH, MDA | [37] |
Breast | MCF-7 | Heartwood | 40–120 µg/mL | ↑ Cell inhibition, inhibited animal fatty acid synthase | - | [39] |
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Rana, N.; Bala, M.; Kumar, V.; Yadav, R.; Jain, N.; Mathew, D.; Bisht, K.; Kumar, R.; Kumar, S. A Systematic Review Exploring the Phytochemical Composition and Anticancer Activities of Acacia catechu. Med. Sci. 2025, 13, 161. https://doi.org/10.3390/medsci13030161
Rana N, Bala M, Kumar V, Yadav R, Jain N, Mathew D, Bisht K, Kumar R, Kumar S. A Systematic Review Exploring the Phytochemical Composition and Anticancer Activities of Acacia catechu. Medical Sciences. 2025; 13(3):161. https://doi.org/10.3390/medsci13030161
Chicago/Turabian StyleRana, Navya, Madhu Bala, Vinod Kumar, Rohitash Yadav, Neeraj Jain, Don Mathew, Khushboo Bisht, Rakesh Kumar, and Sunil Kumar. 2025. "A Systematic Review Exploring the Phytochemical Composition and Anticancer Activities of Acacia catechu" Medical Sciences 13, no. 3: 161. https://doi.org/10.3390/medsci13030161
APA StyleRana, N., Bala, M., Kumar, V., Yadav, R., Jain, N., Mathew, D., Bisht, K., Kumar, R., & Kumar, S. (2025). A Systematic Review Exploring the Phytochemical Composition and Anticancer Activities of Acacia catechu. Medical Sciences, 13(3), 161. https://doi.org/10.3390/medsci13030161