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Case Report

Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat

1
Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland
2
The Scientific Society of Veterinary Medicine Students, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-787 Warsaw, Poland
3
Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Animals 2020, 10(9), 1545; https://doi.org/10.3390/ani10091545
Received: 7 August 2020 / Revised: 28 August 2020 / Accepted: 30 August 2020 / Published: 1 September 2020
(This article belongs to the Section Small Ruminants)
This study presents the first case of a lymphoepithelial cyst (LEC) adjacent to the salivary gland in a goat seropositive for the small ruminant lentivirus (SRLV). Immunohistochemistry detected the antigen of caprine arthritis-encephalitis virus (CAEV) in the LEC, salivary gland, and lung tissue. In human patients, a LEC of the major salivary gland is an uncommon benign lesion and may be the early clinical manifestation of human immunodeficiency virus (HIV) infection. The present report provides useful information on the comparative aspect of LEC in an animal infected with CAEV, one of the SRLVs usually associated with chronic infection. Although many hypothetic theories were proposed, the etiopathogenesis of LEC is still debated. In this study, we present the histopathological description of LEC, supported by histochemistry and immunohistochemistry.
The lymphoepithelial cyst (LEC) of the major salivary gland is a rare lesion described in medical literature. It is found in human immunodeficiency virus (HIV)-infected patients and considered an early manifestation of this infection. Despite the variety of theories, the origin of this lesion remains controversial. No veterinary studies on LEC have been published so far. This study is the first-ever that aims to describe histopathological, histochemical, and immunohistochemical features of a LEC located adjacent to the salivary gland of a goat. The goat proved seropositive for the small ruminant lentivirus, showed clinical signs of caprine arthritis-encephalitis, and had caprine arthritis-encephalitis virus (CAEV)-infected cells in the lung. The histopathology revealed a cystic lesion lined mainly with squamous epithelium surrounded by a lymphoid component, containing a mucus-negative material and a few nonbirefringent structures corresponding to amylase crystalloids. Using immunohistochemistry, CAEV-positive cells were detected in macrophages, LEC epithelial cells, and the salivary gland. The B cells were mainly in the germinal centres, the intraepithelial lymphocytes expressed CD3 and Bcl-2, and the proliferative activity was low. This study showed that LEC had many similar histological and immunohistochemical features to those seen in humans. However, further studies are required in this respect. View Full-Text
Keywords: lymphoepithelial cyst; LEC; salivary gland; goat; CAE; SRLV; histopathology; immunohistochemistry lymphoepithelial cyst; LEC; salivary gland; goat; CAE; SRLV; histopathology; immunohistochemistry
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MDPI and ACS Style

Dolka, I.; Tomaszewski, M.; Wola, D.; Czopowicz, M.; Kaba, J. Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat. Animals 2020, 10, 1545. https://doi.org/10.3390/ani10091545

AMA Style

Dolka I, Tomaszewski M, Wola D, Czopowicz M, Kaba J. Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat. Animals. 2020; 10(9):1545. https://doi.org/10.3390/ani10091545

Chicago/Turabian Style

Dolka, Izabella, Marek Tomaszewski, Daria Wola, Michał Czopowicz, and Jarosław Kaba. 2020. "Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat" Animals 10, no. 9: 1545. https://doi.org/10.3390/ani10091545

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