Next Article in Journal
Indicators of Horse Welfare: State-of-the-Art
Previous Article in Journal
Towards Improving the Outcomes of Assisted Reproductive Technologies of Cattle and Sheep, with Particular Focus on Recipient Management
Open AccessArticle

KA-1002, a Novel Lysophosphatidic Acid Signaling Antagonist, Alleviates Bovine Tracheal Cell Disruption and Inflammation

1
Bio and Drug Discovery Division, Center for Information-Based Drug Research, Research Institute of Chemical Technology (KRICT), Daejeon 305-600, Korea
2
Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea
3
School of Medicine, Chungnam National University, Daejeon 301-747, Korea
4
Department of Microbiology, Chonnam National University Medical School, Gwangju 61468, Korea
*
Author to whom correspondence should be addressed.
Animals 2020, 10(2), 295; https://doi.org/10.3390/ani10020295 (registering DOI)
Received: 24 January 2020 / Accepted: 8 February 2020 / Published: 13 February 2020
(This article belongs to the Section Animal Physiology)
: Bovine respiratory diseases are a key factor reducing the productivity of cows in an industrial livestock environment. We have identified a novel lysophosphatidic acid signaling antagonist, KA-1002, which alleviates lysophosphatidic acid-mediated bovine tracheal cell disruptive tissue injury and inflammation. KA-1002 could be considered a novel therapeutic reagent candidate for maintaining respiratory health in reared cattle.
Abstract: The industrial livestock environment can cause stress and weakened immunity in cattle, leading to microbial infections which reduce productivity. As such, there is a need for an effective therapeutic agent that can alleviate uncontrolled destructive respiratory inflammation. We found that lysophosphatidic acid (LPA), a potent endogenous stress-induced inflammatory agent, causes respiratory tissue damage and triggers inflammation in bovine bronchial cells. LPA also inflames pulmonary bovine blood vessel cells to produce inflammatory cytokines. These findings strongly suggest that LPA is a highly important endogenous material exacerbating bovine respiratory diseases. We further identified a novel LPA-signaling antagonist, KA-1002, and showed that it alleviated LPA-mediated bovine tracheal cell disruption and inflammation. Therefore, KA-1002 could potentially serve as a novel therapeutic agent to maintain physiologically healthy and balanced conditions in bovine respiratory tracts.
Keywords: bovine respiratory disease; lysophosphatidic acid; antagonist; inflammation bovine respiratory disease; lysophosphatidic acid; antagonist; inflammation
MDPI and ACS Style

Shin, H.-S.; Kim, M.; Kim, K.S.; Min, Y.K.; Lee, C.H. KA-1002, a Novel Lysophosphatidic Acid Signaling Antagonist, Alleviates Bovine Tracheal Cell Disruption and Inflammation. Animals 2020, 10, 295.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop