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Article

Changes in Acute Phase Proteins in Bitches after Laparoscopic, Midline, and Flank Ovariectomy Using the Same Method for Hemostasis

1
Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, University CEU—Cardenal Herrera, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain
2
García Cugat Foundation CEU-UCH Chair of Medicine and Regenerative Surgery, University CEU-Cardenal Herrera, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain
3
Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, E-17003 Girona, Spain
4
Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, E-17003 Girona, Spain
5
Unit of Animal Reproduction, Department of Animal Medicine and Surgery, School of Veterinary Medicine, Autonomous University of Barcelona, E-08193 Bellaterra (Cerdanyola Del Vallès), Spain
6
Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Campus of Excellence Mare Nostrum, University of Murcia, Espinardo, 30100 Murcia, Spain
*
Author to whom correspondence should be addressed.
Animals 2020, 10(12), 2223; https://doi.org/10.3390/ani10122223
Received: 19 October 2020 / Revised: 23 November 2020 / Accepted: 23 November 2020 / Published: 27 November 2020
(This article belongs to the Special Issue Biomarkers in Animal Health and Disease)
Ovariectomy is a common surgical procedure in veterinary medicine, with many techniques involved. The aim of this study is to objectively evaluate the acute phase response by measuring the changes in a panel of acute phase proteins after applying three different ovariectomy techniques. C-reactive protein values showed increases of lower magnitude after laparoscopic ovariectomy compared with other techniques, indicating that this surgical technique induces a reduced inflammatory response and tissue damage. The use of this procedure is in agreement with the current tendency to use minimally invasive procedures for ovariectomy.
Acute phase proteins (APP) are biomarkers of systemic inflammation, which allow monitoring the evolution of diseases, the response to treatments, and post-operative complications. Ovariectomy (OVE) is frequently performed in veterinary medicine and can be a useful model to evaluate surgical trauma and inflammation in the bitch. The objective was to investigate and compare the acute phase response (APR) after applying three different OVE techniques by measuring serum levels of C-reactive protein (CRP), haptoglobin (Hp), albumin (Alb), and paraoxonase-1 (PON-1). Forty-five intact bitches were included in the study, being randomly distributed into three groups: laparoscopic OVE (L), midline OVE (M), and flank OVE (F). Serum CRP, Hp, Alb, and PON-1 were measured before surgery, 1, 24, 72, and 168 h post-intervention. CRP levels increased significantly 24 h post-surgery in the M and F groups, but no significant variation was observed in the L group at any time of the study period. Hp was significantly higher in group L than in group F 72 h post-surgery. Alb and PON-1 showed no statistical difference among groups or among sampling periods. CRP response suggests that the use of laparoscopic procedures produce lower inflammation compared to open conventional approaches when performing OVE in the bitch. View Full-Text
Keywords: acute phase proteins; surgical trauma; ovariectomy; laparoscopy acute phase proteins; surgical trauma; ovariectomy; laparoscopy
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MDPI and ACS Style

Del Romero, A.; Cuervo, B.; Peláez, P.; Miguel, L.; Torres, M.; Yeste, M.; Rivera del Alamo, M.M.; Rubio, C.P.; Rubio, M. Changes in Acute Phase Proteins in Bitches after Laparoscopic, Midline, and Flank Ovariectomy Using the Same Method for Hemostasis. Animals 2020, 10, 2223. https://doi.org/10.3390/ani10122223

AMA Style

Del Romero A, Cuervo B, Peláez P, Miguel L, Torres M, Yeste M, Rivera del Alamo MM, Rubio CP, Rubio M. Changes in Acute Phase Proteins in Bitches after Laparoscopic, Midline, and Flank Ovariectomy Using the Same Method for Hemostasis. Animals. 2020; 10(12):2223. https://doi.org/10.3390/ani10122223

Chicago/Turabian Style

Del Romero, Ayla, Belén Cuervo, Pau Peláez, Laura Miguel, Marta Torres, Marc Yeste, Maria Montserrat Rivera del Alamo, Camila P. Rubio, and Mónica Rubio. 2020. "Changes in Acute Phase Proteins in Bitches after Laparoscopic, Midline, and Flank Ovariectomy Using the Same Method for Hemostasis" Animals 10, no. 12: 2223. https://doi.org/10.3390/ani10122223

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