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Article

Long-Term Sinonasal Carriage of Staphylococcus aureus and Anti-Staphylococcal Humoral Immune Response in Patients with Chronic Rhinosinusitis

1
Department of Otorhinolaryngology, Örebro University Hospital, SE 70185 Örebro, Sweden
2
Faculty of Medicine and Health, Örebro University, SE 70182 Örebro, Sweden
3
InfectoGnostics Research Campus, 07743 Jena, Germany
4
Leibniz Institute of Photonic Technology (IPHT), 07743 Jena, Germany
5
Institut fuer Medizinische Mikrobiologie und Hygiene, Medizinische Fakultaet “Carl Gustav Carus” Fiedlerstr. 42, D-01307 Dresden, Germany
6
Institute of Physical Chemistry, Friedrich-Schiller University, 07743 Jena, Germany
7
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, SE 70182 Örebro, Sweden
8
Department of Bacteria, Parasites and Fungi, Statens Serum Institut, 2300 Copenhagen, Denmark
9
Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, SE 70185 Örebro, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Valentina Virginia Ebani
Microorganisms 2021, 9(2), 256; https://doi.org/10.3390/microorganisms9020256
Received: 30 December 2020 / Revised: 23 January 2021 / Accepted: 25 January 2021 / Published: 27 January 2021
(This article belongs to the Special Issue Biology and Pathogenesis of Staphylococcus Infection II)
We investigated Staphylococcus aureus diversity, genetic factors, and humoral immune responses against antigens via genome analysis of S. aureus isolates from chronic rhinosinusitis (CRS) patients in a long-term follow-up. Of the 42 patients who provided S. aureus isolates and serum for a previous study, 34 could be included for follow-up after a decade. Clinical examinations were performed and bacterial samples were collected from the maxillary sinus and nares. S. aureus isolates were characterized by whole-genome sequencing, and specific anti-staphylococcal IgG in serum was determined using protein arrays. S. aureus was detected in the nares and/or maxillary sinus at both initial inclusion and follow-up in 15 of the 34 respondents (44%). Three of these (20%) had S. aureus isolates from the same genetic lineage as at inclusion. A low number of single-nucleotide polymorphisms (SNPs) were identified when comparing isolates from nares and maxillary sinus collected at the same time point. The overall change of antibody responses to staphylococcal antigens over time showed great variability, and no correlation was found between the presence of genes encoding antigens and the corresponding anti-staphylococcal IgG in serum; thus our findings did not support a role, in CRS, of the specific S. aureus antigens investigated. View Full-Text
Keywords: chronic rhinosinusitis; immunoglobulins; Staphylococcus aureus; whole-genome sequencing; enterotoxin; long-term; carriage; antigen chronic rhinosinusitis; immunoglobulins; Staphylococcus aureus; whole-genome sequencing; enterotoxin; long-term; carriage; antigen
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MDPI and ACS Style

Thunberg, U.; Hugosson, S.; Ehricht, R.; Monecke, S.; Müller, E.; Cao, Y.; Stegger, M.; Söderquist, B. Long-Term Sinonasal Carriage of Staphylococcus aureus and Anti-Staphylococcal Humoral Immune Response in Patients with Chronic Rhinosinusitis. Microorganisms 2021, 9, 256. https://doi.org/10.3390/microorganisms9020256

AMA Style

Thunberg U, Hugosson S, Ehricht R, Monecke S, Müller E, Cao Y, Stegger M, Söderquist B. Long-Term Sinonasal Carriage of Staphylococcus aureus and Anti-Staphylococcal Humoral Immune Response in Patients with Chronic Rhinosinusitis. Microorganisms. 2021; 9(2):256. https://doi.org/10.3390/microorganisms9020256

Chicago/Turabian Style

Thunberg, Ulrica, Svante Hugosson, Ralf Ehricht, Stefan Monecke, Elke Müller, Yang Cao, Marc Stegger, and Bo Söderquist. 2021. "Long-Term Sinonasal Carriage of Staphylococcus aureus and Anti-Staphylococcal Humoral Immune Response in Patients with Chronic Rhinosinusitis" Microorganisms 9, no. 2: 256. https://doi.org/10.3390/microorganisms9020256

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