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Open AccessArticle

Different Secondary Metabolite Profiles of Phylogenetically almost Identical Streptomyces griseus Strains Originating from Geographically Remote Locations

1
GEOMAR Helmholtz Centre for Ocean Research Kiel, Marine Microbiology, 24105 Kiel, Germany
2
Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción, 4070386 Concepción, Chile
3
Otto Diels Institute for Organic Chemistry, University of Kiel, 24118 Kiel, Germany
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(6), 166; https://doi.org/10.3390/microorganisms7060166
Received: 8 May 2019 / Revised: 4 June 2019 / Accepted: 4 June 2019 / Published: 6 June 2019
(This article belongs to the Collection Feature Papers in Environmental Microbiology)
As Streptomyces have shown an outstanding capacity for drug production, different campaigns in geographically distant locations currently aim to isolate new antibiotic producers. However, many of these newly isolated Streptomyces strains are classified as identical to already described species. Nevertheless, as discrepancies in terms of secondary metabolites and morphology are possible, we compared two Streptomyces strains with identical 16S rRNA gene sequences but geographically distant origins. Chosen were an Easter Island Streptomyces isolate (Streptomyces sp. SN25_8.1) and the next related type strain, which is Streptomyces griseus subsp. griseus DSM 40236T isolated from Russian garden soil. Compared traits included phylogenetic relatedness based on 16S rRNA gene sequences, macro and microscopic morphology, antibiotic activity and secondary metabolite profiles. Both Streptomyces strains shared several common features, such as morphology and core secondary metabolite production. They revealed differences in pigmentation and in the production of accessory secondary metabolites which appear to be strain-specific. In conclusion, despite identical 16S rRNA classification Streptomyces strains can present different secondary metabolite profiles and may well be valuable for consideration in processes for drug discovery. View Full-Text
Keywords: Streptomyces; geographical isolation; Easter Island; secondary metabolites; 16S rRNA; morphology; High Resolution Mass Spectroscopy (HRMS); Nuclear Magnetic Resonance (NMR); horizontal gene transfer Streptomyces; geographical isolation; Easter Island; secondary metabolites; 16S rRNA; morphology; High Resolution Mass Spectroscopy (HRMS); Nuclear Magnetic Resonance (NMR); horizontal gene transfer
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Sottorff, I.; Wiese, J.; Lipfert, M.; Preußke, N.; Sönnichsen, F.D.; Imhoff, J.F. Different Secondary Metabolite Profiles of Phylogenetically almost Identical Streptomyces griseus Strains Originating from Geographically Remote Locations. Microorganisms 2019, 7, 166.

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