Next Article in Journal
Establishment of a Quality Management System Based on ISO 9001 Standard in a Public Service Fungal Culture Collection
Next Article in Special Issue
Role of Gut Microbiota in Hepatocarcinogenesis
Previous Article in Journal
New Dimensions in Microbial Ecology—Functional Genes in Studies to Unravel the Biodiversity and Role of Functional Microbial Groups in the Environment
Previous Article in Special Issue
Extensive Intestinal Resection Triggers Behavioral Adaptation, Intestinal Remodeling and Microbiota Transition in Short Bowel Syndrome
Open AccessReview

Microbiome, Metabolome and Inflammatory Bowel Disease

Department of Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl Hall East, Kansas City, KS 66160, USA
Department of Internal Medicine and Department of Pediatrics, University of Missouri, Kansas City, MO 64110, USA
Author to whom correspondence should be addressed.
Academic Editor: Carl Gordon Johnston
Microorganisms 2016, 4(2), 20;
Received: 9 March 2016 / Revised: 25 May 2016 / Accepted: 6 June 2016 / Published: 15 June 2016
(This article belongs to the Special Issue Host-Gut Microbiota Metabolic Interactions)
Inflammatory Bowel Disease (IBD) is a multifactorial disorder that conceptually occurs as a result of altered immune responses to commensal and/or pathogenic gut microbes in individuals most susceptible to the disease. During Crohn’s Disease (CD) or Ulcerative Colitis (UC), two components of the human IBD, distinct stages define the disease onset, severity, progression and remission. Epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in IBD pathogenesis. While the dysbiotic microbiota has been proposed to play a role in disease pathogenesis, the data on IBD and diet are still less convincing. Nonetheless, studies are ongoing to examine the effect of pre/probiotics and/or FODMAP reduced diets on both the gut microbiome and its metabolome in an effort to define the healthy diet in patients with IBD. Knowledge of a unique metabolomic fingerprint in IBD could be useful for diagnosis, treatment and detection of disease pathogenesis. View Full-Text
Keywords: microbiome; metabolome; metabolites; dysbiosis; inflammation bowel diseases; prebiotics; probiotics microbiome; metabolome; metabolites; dysbiosis; inflammation bowel diseases; prebiotics; probiotics
Show Figures

Graphical abstract

MDPI and ACS Style

Ahmed, I.; Roy, B.C.; Khan, S.A.; Septer, S.; Umar, S. Microbiome, Metabolome and Inflammatory Bowel Disease. Microorganisms 2016, 4, 20.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop