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Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021

1
Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
2
Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
3
Human Link, Dubai 971, United Arab Emirates
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Jason Mackenzie
Microorganisms 2022, 10(3), 595; https://doi.org/10.3390/microorganisms10030595
Received: 17 February 2022 / Revised: 4 March 2022 / Accepted: 7 March 2022 / Published: 9 March 2022
(This article belongs to the Section Veterinary Microbiology)
In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates in Egypt from 2017 to 2021 detected at least six genotypes of Highly Pathogenic Avian Influenza (HPAI) H5N8 viruses with evidence of partial or complete annual replacement of dominant strains. Although all Egyptian H5N8 viruses had clade 2.3.4.4b hemagglutinin (HA) genes, the remaining viral gene segments were from multiple geographic origins, indicating that the H5N8 isolates resulted from multiple introductions. Mutations in the viral proteins associated with pathogenicity and antiviral drug resistance were detected. Some mutations in the HA resulted in antigenic drift. Heterogeneity in circulating H5N8 HPAI threatens poultry production and public health. View Full-Text
Keywords: Egypt; highly pathogenic avian influenza; H5N8; phylogenetic analysis; reassortment Egypt; highly pathogenic avian influenza; H5N8; phylogenetic analysis; reassortment
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MDPI and ACS Style

Kandeil, A.; Moatasim, Y.; El Taweel, A.; El Sayes, M.; Rubrum, A.; Jeevan, T.; McKenzie, P.P.; Webby, R.J.; Ali, M.A.; Kayali, G.; El-Shesheny, R. Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021. Microorganisms 2022, 10, 595. https://doi.org/10.3390/microorganisms10030595

AMA Style

Kandeil A, Moatasim Y, El Taweel A, El Sayes M, Rubrum A, Jeevan T, McKenzie PP, Webby RJ, Ali MA, Kayali G, El-Shesheny R. Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021. Microorganisms. 2022; 10(3):595. https://doi.org/10.3390/microorganisms10030595

Chicago/Turabian Style

Kandeil, Ahmed, Yassmin Moatasim, Ahmed El Taweel, Mohamed El Sayes, Adam Rubrum, Trushar Jeevan, Pamela P. McKenzie, Richard J. Webby, Mohamed A. Ali, Ghazi Kayali, and Rabeh El-Shesheny. 2022. "Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021" Microorganisms 10, no. 3: 595. https://doi.org/10.3390/microorganisms10030595

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