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Article

Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1

1
ABITEP GmbH, Glienicker Weg 185, 12489 Berlin, Germany
2
Institute of Environmental Biotechnology, Graz University of Technology, Petergasse 12, 8010 Graz, Austria
3
Robert Koch-Institut, ZBS6, Proteomics and Spectroscopy, Seestr 10, 13353 Berlin, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Huijun Wu and Xuewen Gao
Pathogens 2021, 10(11), 1485; https://doi.org/10.3390/pathogens10111485
Received: 18 October 2021 / Revised: 9 November 2021 / Accepted: 9 November 2021 / Published: 15 November 2021
Paenibacilli are efficient producers of potent agents against bacterial and fungal pathogens, which are of great interest both for therapeutic applications in medicine as well as in agrobiotechnology. Lipopeptides produced by such organisms play a major role in their potential to inactivate pathogens. In this work we investigated two lipopeptide complexes, the fusaricidins and the polymyxins, produced by Paenibacillus polymyxa strains DSM 32871 and M1 by MALDI-TOF mass spectrometry. The fusaricidins show potent antifungal activities and are distinguished by an unusual variability. For strain DSM 32871 we identified numerous yet unknown variants mass spectrometrically. DSM 32871 produces polymyxins of type E (colistins), while M1 forms polymyxins P. For both strains, novel but not yet completely characterized polymyxin species were detected, which possibly are glycosylated. These compounds may be of interest therapeutically, because polymyxins have gained increasing attention as last-resort antibiotics against multiresistant pathogenic Gram-negative bacteria. In addition, the volatilomes of DSM 32781 and M1 were investigated with a GC–MS approach using different cultivation media. Production of volatile organic compounds (VOCs) was strain and medium dependent. In particular, strain M1 manifested as an efficient VOC-producer that exhibited formation of 25 volatiles in total. A characteristic feature of Paenibacilli is the formation of volatile pyrazine derivatives. View Full-Text
Keywords: P. polymyxa; bioactive peptides; volatiles; MALDI-TOF mass spectrometry; GC–MS P. polymyxa; bioactive peptides; volatiles; MALDI-TOF mass spectrometry; GC–MS
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MDPI and ACS Style

Mülner, P.; Schwarz, E.; Dietel, K.; Herfort, S.; Jähne, J.; Lasch, P.; Cernava, T.; Berg, G.; Vater, J. Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1. Pathogens 2021, 10, 1485. https://doi.org/10.3390/pathogens10111485

AMA Style

Mülner P, Schwarz E, Dietel K, Herfort S, Jähne J, Lasch P, Cernava T, Berg G, Vater J. Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1. Pathogens. 2021; 10(11):1485. https://doi.org/10.3390/pathogens10111485

Chicago/Turabian Style

Mülner, Pascal, Elisa Schwarz, Kristin Dietel, Stefanie Herfort, Jennifer Jähne, Peter Lasch, Tomislav Cernava, Gabriele Berg, and Joachim Vater. 2021. "Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1" Pathogens 10, no. 11: 1485. https://doi.org/10.3390/pathogens10111485

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