Next Article in Journal
Effects of Grain Boundary Microconstituents on Heat-Affected Zone Cracks in a Mar-M004 Weldment
Next Article in Special Issue
Evaluation of Fatigue Behavior in Dental Implants from In Vitro Clinical Tests: A Systematic Review
Previous Article in Journal
The Effect of Low-Quantity Cr Addition on the Corrosion Behaviour of Dual-Phase High Carbon Steel
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Metals 2018, 8(4), 200; https://doi.org/10.3390/met8040200

Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds

1
Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia
2
Monash Centre for Additive Manufacturing, Monash University, Clayton, VIC 3800, Australia
*
Authors to whom correspondence should be addressed.
Received: 15 February 2018 / Revised: 16 March 2018 / Accepted: 19 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Titanium Alloys for Biomedical Implants and Devices)
  |  
PDF [4273 KB, uploaded 3 May 2018]
  |  

Abstract

Functionally graded lattice structures produced by additive manufacturing are promising for bone tissue engineering. Spatial variations in their porosity are reported to vary the stiffness and make it comparable to cortical or trabecular bone. However, the interplay between the mechanical properties and biological response of functionally graded lattices is less clear. Here we show that by designing continuous gradient structures and studying their mechanical and biological properties simultaneously, orthopedic implant design can be improved and guidelines can be established. Our continuous gradient structures were generated by gradually changing the strut diameter of a body centered cubic (BCC) unit cell. This approach enables a smooth transition between unit cell layers and minimizes the effect of stress discontinuity within the scaffold. Scaffolds were fabricated using selective laser melting (SLM) and underwent mechanical and in vitro biological testing. Our results indicate that optimal gradient structures should possess small pores in their core (~900 µm) to increase their mechanical strength whilst large pores (~1100 µm) should be utilized in their outer surface to enhance cell penetration and proliferation. We suggest this approach could be widely used in the design of orthopedic implants to maximize both the mechanical and biological properties of the implant. View Full-Text
Keywords: selective laser melting; gradient structure; porous biomaterial; Ti6Al4V; mechanical properties; osteoblast selective laser melting; gradient structure; porous biomaterial; Ti6Al4V; mechanical properties; osteoblast
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Onal, E.; Frith, J.E.; Jurg, M.; Wu, X.; Molotnikov, A. Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds. Metals 2018, 8, 200.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Metals EISSN 2075-4701 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top