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Open AccessArticle

Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy

1
Department of Materials Science and Engineering, National Cheng Kung University, Tainan 701, Taiwan
2
Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan
*
Authors to whom correspondence should be addressed.
Metals 2017, 7(11), 481; https://doi.org/10.3390/met7110481
Received: 21 September 2017 / Revised: 27 October 2017 / Accepted: 3 November 2017 / Published: 6 November 2017
(This article belongs to the Special Issue Biodegradable Metals)
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Abstract

This study aimed to develop and evaluate the ECO-friendly Mg-5Zn-0.5Zr (ECO505) alloy for application in dental-guided bone regeneration (GBR). The microstructure and surface properties of biomedical Mg materials greatly influence anti-corrosion performance and biocompatibility. Accordingly, for the purpose of microstructure and surface modification, heat treatments and surface coatings were chosen to provide varied functional characteristics. We developed and integrated both an optimized solution heat-treatment condition and surface fluoride coating technique to fabricate a Mg-based regeneration membrane. The heat-treated Mg regeneration membrane (ARRm-H380) and duplex-treated regeneration membrane group (ARRm-H380-F24 h) were thoroughly investigated to characterize the mechanical properties, as well as the in vitro corrosion and in vivo degradation behaviors. Significant enhancement in ductility and corrosion resistance for the ARRm-H380 was obtained through the optimized solid-solution heat treatment; meanwhile, the corrosion resistance of ARRm-H380-F24 h showed further improvement, resulting in superior substrate integrity. In addition, the ARRm-H380 provided the proper amount of Mg-ion concentration to accelerate bone growth in the early stage (more than 80% new bone formation). From a specific biomedical application point of view, these research results point out a successful manufacturing route and suggest that the heat treatment and duplex treatment could be employed to offer custom functional regeneration membranes for different clinical patients. View Full-Text
Keywords: Mg alloy; regeneration membrane; guided bone regeneration; heat treatment; fluoride coating; biocompatibility Mg alloy; regeneration membrane; guided bone regeneration; heat treatment; fluoride coating; biocompatibility
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Lin, D.-J.; Hung, F.-Y.; Lee, H.-P.; Yeh, M.-L. Development of a Novel Degradation-Controlled Magnesium-Based Regeneration Membrane for Future Guided Bone Regeneration (GBR) Therapy. Metals 2017, 7, 481.

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