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Article

Antibiotic Prescription and In-Hospital Mortality in COVID-19: A Prospective Multicentre Cohort Study

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Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
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Department of Internal Medicine, Colentina Clinical Hospital, 020125 Bucharest, Romania
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Clinical Research Unit, Reseau d’Epidemiologie Clinique International Francophone, 020125 Bucharest, Romania
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Department of Internal Medicine, Clinical Emergency Hospital Sfantul Spiridon, 700111 Iasi, Romania
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Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania
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Department of Infectious Diseases, National Institute for Infectious Diseases Prof. Dr. Matei Bals, 021105 Bucharest, Romania
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Department of Pneumology, Colentina Clinical Hospital, 020125 Bucharest, Romania
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Faculty of Medicine, Ovidius University, 900527 Constanta, Romania
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Department of Infectious Diseases, Clinical Hospital of Infectious Diseases, 900178 Constanta, Romania
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Department of Internal Medicine, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania
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Department of Internal Medicine, Craiova Emergency County Hospital, 200642 Craiova, Romania
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Department of Internal Medicine, Sacele County Hospital, 505600 Brasov, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Paraskevi Katsaounou and Miguel A. Ortega
J. Pers. Med. 2022, 12(6), 877; https://doi.org/10.3390/jpm12060877
Received: 3 April 2022 / Revised: 3 May 2022 / Accepted: 23 May 2022 / Published: 26 May 2022
(This article belongs to the Special Issue Personalized Medicine for Covid-19 Patients-Clinical Considerations)
Background: Since the beginning of the COVID-19 pandemic, empiric antibiotics (ATBs) have been prescribed on a large scale in both in- and outpatients. We aimed to assess the impact of antibiotic treatment on the outcomes of hospitalised patients with moderate and severe coronavirus disease 2019 (COVID-19). Methods: We conducted a prospective multicentre cohort study in six clinical hospitals, between January 2021 and May 2021. Results: We included 553 hospitalised COVID-19 patients, of whom 58% (311/553) were prescribed antibiotics, while bacteriological tests were performed in 57% (178/311) of them. Death was the outcome in 48 patients—39 from the ATBs group and 9 from the non-ATBs group. The patients who received antibiotics during hospitalisation had a higher mortality (RR = 3.37, CI 95%: 1.7–6.8), and this association was stronger in the subgroup of patients without reasons for antimicrobial treatment (RR = 6.1, CI 95%: 1.9–19.1), while in the subgroup with reasons for antimicrobial therapy the association was not statistically significant (OR = 2.33, CI 95%: 0.76–7.17). After adjusting for the confounders, receiving antibiotics remained associated with a higher mortality only in the subgroup of patients without criteria for antibiotic prescription (OR = 10.3, CI 95%: 2–52). Conclusions: In our study, antibiotic treatment did not decrease the risk of death in the patients with mild and severe COVID-19, but was associated with a higher risk of death in the subgroup of patients without reasons for it. View Full-Text
Keywords: antibiotics; antibacterial agents; COVID-19; SARS-CoV-2; mortality; hospital mortality; cohort studies; prospective studies antibiotics; antibacterial agents; COVID-19; SARS-CoV-2; mortality; hospital mortality; cohort studies; prospective studies
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MDPI and ACS Style

Pinte, L.; Ceasovschih, A.; Niculae, C.-M.; Stoichitoiu, L.E.; Ionescu, R.A.; Balea, M.I.; Cernat, R.C.; Vlad, N.; Padureanu, V.; Purcarea, A.; Badea, C.; Hristea, A.; Sorodoc, L.; Baicus, C. Antibiotic Prescription and In-Hospital Mortality in COVID-19: A Prospective Multicentre Cohort Study. J. Pers. Med. 2022, 12, 877. https://doi.org/10.3390/jpm12060877

AMA Style

Pinte L, Ceasovschih A, Niculae C-M, Stoichitoiu LE, Ionescu RA, Balea MI, Cernat RC, Vlad N, Padureanu V, Purcarea A, Badea C, Hristea A, Sorodoc L, Baicus C. Antibiotic Prescription and In-Hospital Mortality in COVID-19: A Prospective Multicentre Cohort Study. Journal of Personalized Medicine. 2022; 12(6):877. https://doi.org/10.3390/jpm12060877

Chicago/Turabian Style

Pinte, Larisa, Alexandr Ceasovschih, Cristian-Mihail Niculae, Laura Elena Stoichitoiu, Razvan Adrian Ionescu, Marius Ioan Balea, Roxana Carmen Cernat, Nicoleta Vlad, Vlad Padureanu, Adrian Purcarea, Camelia Badea, Adriana Hristea, Laurenţiu Sorodoc, and Cristian Baicus. 2022. "Antibiotic Prescription and In-Hospital Mortality in COVID-19: A Prospective Multicentre Cohort Study" Journal of Personalized Medicine 12, no. 6: 877. https://doi.org/10.3390/jpm12060877

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