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Article

Dementia Risk among Coronavirus Disease Survivors: A Nationwide Cohort Study in South Korea

by 1,2,†, 3,† and 3,4,*
1
Department of Psychiatry, Seoul National University Hospital, Seoul 03080, Korea
2
Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Korea
3
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea
4
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul 03080, Korea
*
Author to whom correspondence should be addressed.
Made an equal contribution as co-first author.
Academic Editors: Weikuan Gu and Lotfi Aleya
J. Pers. Med. 2021, 11(10), 1015; https://doi.org/10.3390/jpm11101015
Received: 5 September 2021 / Revised: 1 October 2021 / Accepted: 8 October 2021 / Published: 9 October 2021
(This article belongs to the Special Issue Personalized Medicine and Management of COVID-19)
We aimed to investigate whether coronavirus disease (COVID-19) survivors were at a higher risk of dementia diagnosis compared to controls at 6 months follow-up. Data pertaining to the period between 1 January and 4 June 2020, were extracted from the National Health Insurance Service (NHIS)-COVID-19 database in South Korea. Data on adults (≥20 years old) with no history of dementia, obtained from the NHIS-COVID-19 database, were included in the study. The endpoint of this study was the development of dementia, which was evaluated from 1 January to 1 December 2020. A total of 306,577 adults were included in the analysis, comprising 7133 COVID-19 survivors and 299,444 individuals in the control group. Among the subjects, new-onset dementia diagnosed in 2020 was recorded in 1.2% (3546 of 306,577). In the covariate-adjusted multivariable Cox regression model, the incidence of dementia among COVID-19 survivors was 1.39-fold higher (hazard ratio: 1.39, 95% confidence interval: 1.05–1.85; p = 0.023) than that in the control group. At approximately 6 months of follow-up, COVID-19 survivors were at a higher risk of dementia compared to other populations in South Korea. View Full-Text
Keywords: COVID-19; COVID-19 survivors; dementia; Alzheimer’s disease; vascular dementia COVID-19; COVID-19 survivors; dementia; Alzheimer’s disease; vascular dementia
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MDPI and ACS Style

Park, H.-Y.; Song, I.-A.; Oh, T.-K. Dementia Risk among Coronavirus Disease Survivors: A Nationwide Cohort Study in South Korea. J. Pers. Med. 2021, 11, 1015. https://doi.org/10.3390/jpm11101015

AMA Style

Park H-Y, Song I-A, Oh T-K. Dementia Risk among Coronavirus Disease Survivors: A Nationwide Cohort Study in South Korea. Journal of Personalized Medicine. 2021; 11(10):1015. https://doi.org/10.3390/jpm11101015

Chicago/Turabian Style

Park, Hye-Yoon, In-Ae Song, and Tak-Kyu Oh. 2021. "Dementia Risk among Coronavirus Disease Survivors: A Nationwide Cohort Study in South Korea" Journal of Personalized Medicine 11, no. 10: 1015. https://doi.org/10.3390/jpm11101015

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