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Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease

Obesity and Metabolic Health Laboratory, Department of Nutritional Sciences, Texas Tech University, Lubbock, TX 79409, USA
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J. Pers. Med. 2020, 10(2), 42; https://doi.org/10.3390/jpm10020042
Received: 17 April 2020 / Revised: 16 May 2020 / Accepted: 19 May 2020 / Published: 22 May 2020
(This article belongs to the Special Issue Novel Biomarkers in Alzheimer’s Disease)
Alzheimer’s disease (AD) is the sixth leading cause of death and is correlated with obesity, which is the second leading cause of preventable diseases in the United States. Obesity, diabetes, and AD share several common features, and inflammation emerges as the central link. High-calorie intake, elevated free fatty acids, and impaired endocrine function leads to insulin resistance and systemic inflammation. Systemic inflammation triggers neuro-inflammation, which eventually hinders the metabolic and regulatory function of the brain mitochondria leading to neuronal damage and subsequent AD-related cognitive decline. As an early event in the pathogenesis of AD, chronic inflammation could be considered as a potential biomarker in the treatment strategies for AD. View Full-Text
Keywords: obesity; diabetes; inflammation; Alzheimer’s disease; Amyloid Beta; Tau; biomarker; mitochondrial dysfunction obesity; diabetes; inflammation; Alzheimer’s disease; Amyloid Beta; Tau; biomarker; mitochondrial dysfunction
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Khan, M.S.H.; Hegde, V. Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease. J. Pers. Med. 2020, 10, 42.

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