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A Brief Overview of Medical Fiber Optic Biosensors and Techniques in the Modification for Enhanced Sensing Ability

Department of Biomedical Engineering, Widener University, Chester, PA 19013, USA
Author to whom correspondence should be addressed.
Diagnostics 2019, 9(1), 23;
Received: 12 February 2019 / Revised: 23 February 2019 / Accepted: 24 February 2019 / Published: 27 February 2019
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In this paper, we provide a brief overview of fiber optic biosensors for use in MedTech, specifically to aid in the diagnoses and treatment of those with chronic medical conditions. Fiber optic cables as components of biological sensors make them especially effective in biological systems that may require ultra-sensitive detection of low-frequency signals in hard to reach areas. This systematic review focuses on the differentiating factors of fiber-optic biosensors, which are tailored to apply the sensor to specific health needs. The main components of FOBS (fiber optic biosensors) such as biosensing elements, fiber optic cables, optical element enhancements, transducers, sensing strategies, photodetectors, and signal processing are covered in detail by showcasing the recent developments in modifications to these components. This paper pays particular attention to the alterations made in biosensing elements including pH elements, enzymatic elements, as well as those sensors utilizing antibodies and whole-cell bacteria. This paper reviews and discusses several published examples in the research stage of development to give the reader an overall scope of the field. The need for research on biosensing equipment is increasing, as the number of individuals with chronic diseases and the geriatric population require more effective, accurate, and mobile sensing ability and reduced invasiveness. FOBS offer a sensing solution that is accurate, tailorable to almost any clinical need, has abundant and relatively cheap material requirements, and a well-established technological base in fiber optic technology. This small price tag and large market potential make FOBS a desirable research area. View Full-Text
Keywords: biosensors; fiber optic sensors; immunosensors biosensors; fiber optic sensors; immunosensors

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Mowbray, S.E.; Amiri, A.M. A Brief Overview of Medical Fiber Optic Biosensors and Techniques in the Modification for Enhanced Sensing Ability. Diagnostics 2019, 9, 23.

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