Next Article in Journal / Special Issue
Ovarian Cancer Incidence Corrected for Oophorectomy
Previous Article in Journal
Detecting Breast Cancer with a Dual-Modality Device
Previous Article in Special Issue
Complications from Surgeries Related to Ovarian Cancer Screening
Open AccessArticle

Symptoms Relevant to Surveillance for Ovarian Cancer

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Chandler Medical Center-Markey Cancer Center, Lexington, KY 40536-0293, USA
Department of Statistics, University of Kentucky Chandler Medical Center-Markey Cancer Center, Lexington, KY 40536-0293, USA
Author to whom correspondence should be addressed.
Academic Editor: Andreas Kjaer
Diagnostics 2017, 7(1), 18;
Received: 13 December 2016 / Revised: 1 March 2017 / Accepted: 13 March 2017 / Published: 20 March 2017
(This article belongs to the Special Issue Ovarian Cancer Screening)
To examine how frequently and confidently healthy women report symptoms during surveillance for ovarian cancer. A symptoms questionnaire was administered to 24,526 women over multiple visits accounting for 70,734 reports. A query of reported confidence was included as a confidence score (CS). Chi square, McNemars test, ANOVA and multivariate analyses were performed. 17,623 women completed the symptoms questionnaire more than one time and >9500 women completed it more than one four times for >43,000 serially completed questionnaires. Reporting ovarian cancer symptoms was ~245 higher than ovarian cancer incidence. The positive predictive value (0.073%) for identifying ovarian cancer based on symptoms alone would predict one malignancy for 1368 cases taken to surgery due to reported symptoms. Confidence on the first questionnaire (83.3%) decreased to 74% when more than five questionnaires were completed. Age-related decreases in confidence were significant (p < 0.0001). Women reporting at least one symptom expressed more confidence (41,984/52,379 = 80.2%) than women reporting no symptoms (11,882/18,355 = 64.7%), p < 0.0001. Confidence was unrelated to history of hormone replacement therapy or abnormal ultrasound findings (p = 0.30 and 0.89). The frequency of symptoms relevant to ovarian cancer was much higher than the occurrence of ovarian cancer. Approximately 80.1% of women expressed confidence in what they reported. View Full-Text
Keywords: symptoms; questionnaire; certainty/uncertainty symptoms; questionnaire; certainty/uncertainty
Show Figures

Figure 1

MDPI and ACS Style

Ore, R.M.; Baldwin, L.; Woolum, D.; Elliott, E.; Wijers, C.; Chen, C.-Y.; Miller, R.W.; DeSimone, C.P.; Ueland, F.R.; Kryscio, R.J.; Nagell, J.R.; Pavlik, E.J. Symptoms Relevant to Surveillance for Ovarian Cancer. Diagnostics 2017, 7, 18.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop