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Article

Characterization of the COPD Salivary Fingerprint through Surface Enhanced Raman Spectroscopy: A Pilot Study

IRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy
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Academic Editor: Koichi Nishimura
Diagnostics 2021, 11(3), 508; https://doi.org/10.3390/diagnostics11030508
Received: 24 February 2021 / Revised: 10 March 2021 / Accepted: 11 March 2021 / Published: 12 March 2021
(This article belongs to the Special Issue Diagnosis, Treatment, and Management of COPD and Asthma)
Chronic Obstructive Pulmonary Disease (COPD) is a debilitating pathology characterized by reduced lung function, breathlessness and rapid and unrelenting decrease in quality of life. The severity rate and the therapy selection are strictly dependent on various parameters verifiable after years of clinical observations, missing a direct biomarker associated with COPD. In this work, we report the methodological application of Surface Enhanced Raman Spectroscopy combined with Multivariate statistics for the analysis of saliva samples collected from 15 patients affected by COPD and 15 related healthy subjects in a pilot study. The comparative Raman analysis allowed to determine a specific signature of the pathological saliva, highlighting differences in determined biological species, already studied and characterized in COPD onset, compared to the Raman signature of healthy samples. The unsupervised principal component analysis and hierarchical clustering revealed a sharp data dispersion between the two experimental groups. Using the linear discriminant analysis, we created a classification model able to discriminate the collected signals with accuracies, specificities, and sensitivities of more than 98%. The results of this preliminary study are promising for further applications of Raman spectroscopy in the COPD clinical field. View Full-Text
Keywords: SERS; COPD; multivariate analysis; saliva SERS; COPD; multivariate analysis; saliva
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MDPI and ACS Style

Carlomagno, C.; Gualerzi, A.; Picciolini, S.; Rodà, F.; Banfi, P.I.; Lax, A.; Bedoni, M. Characterization of the COPD Salivary Fingerprint through Surface Enhanced Raman Spectroscopy: A Pilot Study. Diagnostics 2021, 11, 508. https://doi.org/10.3390/diagnostics11030508

AMA Style

Carlomagno C, Gualerzi A, Picciolini S, Rodà F, Banfi PI, Lax A, Bedoni M. Characterization of the COPD Salivary Fingerprint through Surface Enhanced Raman Spectroscopy: A Pilot Study. Diagnostics. 2021; 11(3):508. https://doi.org/10.3390/diagnostics11030508

Chicago/Turabian Style

Carlomagno, Cristiano; Gualerzi, Alice; Picciolini, Silvia; Rodà, Francesca; Banfi, Paolo I.; Lax, Agata; Bedoni, Marzia. 2021. "Characterization of the COPD Salivary Fingerprint through Surface Enhanced Raman Spectroscopy: A Pilot Study" Diagnostics 11, no. 3: 508. https://doi.org/10.3390/diagnostics11030508

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