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Chemomimesis and Molecular Darwinism in Action: From Abiotic Generation of Nucleobases to Nucleosides and RNA

Biological and Ecological Department, University of Tuscia, 01100 Viterbo, Italy
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61265 Brno, Czech Republic
Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy
Authors to whom correspondence should be addressed.
Received: 23 May 2018 / Revised: 14 June 2018 / Accepted: 19 June 2018 / Published: 20 June 2018
PDF [694 KB, uploaded 20 June 2018]


Molecular Darwinian evolution is an intrinsic property of reacting pools of molecules resulting in the adaptation of the system to changing conditions. It has no a priori aim. From the point of view of the origin of life, Darwinian selection behavior, when spontaneously emerging in the ensembles of molecules composing prebiotic pools, initiates subsequent evolution of increasingly complex and innovative chemical information. On the conservation side, it is a posteriori observed that numerous biological processes are based on prebiotically promptly made compounds, as proposed by the concept of Chemomimesis. Molecular Darwinian evolution and Chemomimesis are principles acting in balanced cooperation in the frame of Systems Chemistry. The one-pot synthesis of nucleosides in radical chemistry conditions is possibly a telling example of the operation of these principles. Other indications of similar cases of molecular evolution can be found among biogenic processes. View Full-Text
Keywords: origin of life; systems chemistry; Chemomimesis; Molecular Darwinism origin of life; systems chemistry; Chemomimesis; Molecular Darwinism

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Saladino, R.; Šponer, J.E.; Šponer, J.; Costanzo, G.; Pino, S.; Di Mauro, E. Chemomimesis and Molecular Darwinism in Action: From Abiotic Generation of Nucleobases to Nucleosides and RNA. Life 2018, 8, 24.

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