Enantioselective Catalytic Synthesis of N-alkylated Indoles
Abstract
:1. Introduction
2. Direct Organocatalytic Methods
2.1. N-Allylations with Morita-Baylis-Hillman Adducts
2.2. N-Selective Additions to α-Oxoaldehydes
2.3. N-Selective Additions of Indoles to Imine/Iminium Activated Adducts
2.4. Aza-Michael Additions
2.5. N-Heterocyclic Carbene-Mediated Cyclizations
3. Organocatalytic Indirect Methods
4. Direct Organometallic Methods
4.1. C2-Selective Addition/N-Cyclization Sequences
4.2. N-Allylation of Indoles
4.3. Aminations of Alkenes with Indoles
4.4. Copper-Catalyzed N-Selective Additions of Indoles to Alkylhalides
5. Other Direct Methods
6. Transition-Metal Catalyzed Indirect Methods
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Trubitsõn, D.; Kanger, T. Enantioselective Catalytic Synthesis of N-alkylated Indoles. Symmetry 2020, 12, 1184. https://doi.org/10.3390/sym12071184
Trubitsõn D, Kanger T. Enantioselective Catalytic Synthesis of N-alkylated Indoles. Symmetry. 2020; 12(7):1184. https://doi.org/10.3390/sym12071184
Chicago/Turabian StyleTrubitsõn, Dmitri, and Tõnis Kanger. 2020. "Enantioselective Catalytic Synthesis of N-alkylated Indoles" Symmetry 12, no. 7: 1184. https://doi.org/10.3390/sym12071184