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Genes 2018, 9(2), 61;

Another Round of “Clue” to Uncover the Mystery of Complex Traits

The Huck Institute of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Author to whom correspondence should be addressed.
Received: 1 November 2017 / Revised: 19 December 2017 / Accepted: 15 January 2018 / Published: 25 January 2018
(This article belongs to the Special Issue Complex Genetic Loci)
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A plethora of genetic association analyses have identified several genetic risk loci. Technological and statistical advancements have now led to the identification of not only common genetic variants, but also low-frequency variants, structural variants, and environmental factors, as well as multi-omics variations that affect the phenotypic variance of complex traits in a population, thus referred to as complex trait architecture. The concept of heritability, or the proportion of phenotypic variance due to genetic inheritance, has been studied for several decades, but its application is mainly in addressing the narrow sense heritability (or additive genetic component) from Genome-Wide Association Studies (GWAS). In this commentary, we reflect on our perspective on the complexity of understanding heritability for human traits in comparison to model organisms, highlighting another round of clues beyond GWAS and an alternative approach, investigating these clues comprehensively to help in elucidating the genetic architecture of complex traits. View Full-Text
Keywords: complex traits; meta-dimensional analysis; multi-omics datasets; heritability; game of “Clue” complex traits; meta-dimensional analysis; multi-omics datasets; heritability; game of “Clue”

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Verma, S.S.; Ritchie, M.D. Another Round of “Clue” to Uncover the Mystery of Complex Traits. Genes 2018, 9, 61.

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