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Genes 2015, 6(2), 417-435;

Hedgehog Signaling during Appendage Development and Regeneration

Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA
Author to whom correspondence should be addressed.
Academic Editor: Paul Cahill
Received: 4 April 2015 / Revised: 28 May 2015 / Accepted: 5 June 2015 / Published: 23 June 2015
(This article belongs to the Special Issue Hedgehog Signaling Gene Regulatory Networks)
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Regulatory networks that govern embryonic development have been well defined. While a common hypothesis supports the notion that the embryonic regulatory cascades are reexpressed following injury and tissue regeneration, the mechanistic regulatory pathways that mediate the regenerative response in higher organisms remain undefined. Relative to mammals, lower vertebrates, including zebrafish and newts, have a tremendous regenerative capacity to repair and regenerate a number of organs including: appendages, retina, heart, jaw and nervous system. Elucidation of the pathways that govern regeneration in these lower organisms may provide cues that will enhance the capacity for the regeneration of mammalian organs. Signaling pathways, such as the hedgehog pathway, have been shown to play critical functions during development and during regeneration in lower organisms. These signaling pathways have been shown to modulate multiple processes including cellular origin, positional identity and cellular maturation. The present review will focus on the cellular and molecular regulation of the hedgehog (HH) signaling pathway and its interaction with other signaling factors during appendage development and regeneration. View Full-Text
Keywords: signaling pathways; hedgehog signaling; limb development; regeneration signaling pathways; hedgehog signaling; limb development; regeneration

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Singh, B.N.; Koyano-Nakagawa, N.; Donaldson, A.; Weaver, C.V.; Garry, M.G.; Garry, D.J. Hedgehog Signaling during Appendage Development and Regeneration. Genes 2015, 6, 417-435.

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