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Genes, Volume 15, Issue 9

September 2024 - 131 articles

Cover Story: The article delves into the critical role of the RHO gene in Autosomal Dominant Retinitis Pigmentosa (AD-RP) cases within Italy. Through a retrospective analysis of Italian patients clinically suspected of RP, eight RHO variants were identified. Among these, four pathogenic variants (c.632A>T, c.1040C>T, c.1030C>T, c.383_392del) were confirmed, solidifying the AD-RP diagnosis in nine affected individuals. Interestingly, the study revealed a lower-than-expected frequency (17%) of RHO variants compared to previous findings. Additionally, four variants were classified as VUS, underscoring the complexity of the RHO gene's involvement in RP. This research offers a comprehensive overview of RHO variant distribution in the Italian population, paving the way for further investigations into the broader spectrum of diseases associated with this gene. View this paper
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Articles (131)

  • Article
  • Open Access
1 Citations
1,842 Views
18 Pages

23 September 2024

Background/Objectives: Rehmannia glutinosa, a highly valuable medicinal plant in China, is encountering severe replant disease. Replant disease represents a complex stress driven by multiple principal factors (RDFs), including allelochemicals, microb...

  • Article
  • Open Access
5 Citations
2,084 Views
15 Pages

dmrt1 Is Responsible for Androgen-Induced Masculinization in Nile Tilapia

  • Shengfei Dai,
  • Mei Li,
  • Jie Yuan,
  • Xueyan Wei,
  • Eryan Ma,
  • Deshou Wang and
  • Minghui Li

23 September 2024

17α-Methyltestosterone (MT) is a widely used androgen for all-male fish production in aquaculture. However, the molecular mechanism underlying MT-induced masculinization remains unclear. In this study, we aim to identify the key gene responsibl...

  • Review
  • Open Access
15 Citations
6,015 Views
32 Pages

The Past, Present, and Future of Plant Activators Targeting the Salicylic Acid Signaling Pathway

  • Misbah Naz,
  • Dongqin Zhang,
  • Kangcen Liao,
  • Xulong Chen,
  • Nazeer Ahmed,
  • Delu Wang,
  • Jingjiang Zhou and
  • Zhuo Chen

23 September 2024

Plant activators have emerged as promising alternatives to conventional crop protection chemicals for managing crop diseases due to their unique mode of action. By priming the plant’s innate immune system, these compounds can induce disease res...

  • Article
  • Open Access
5 Citations
2,151 Views
24 Pages

23 September 2024

Background: For the past 25 years, the ITS rDNA (ITS1-5.8S-ITS2) of Gyrodactylidae has been crucial for species identification, description, and phylogeny. This family includes 25 genera parasitizing marine and freshwater fish, initially distinguishe...

  • Article
  • Open Access
3 Citations
1,980 Views
10 Pages

23 September 2024

Background/Objectives: Nitrogen is an essential macroelement for plant growth and productivity. Calcium (Ca2+) acts as a critical second messenger in numerous adaptations and developmental processes in plants. The Calcineurin B-like protein (CBL)-int...

  • Review
  • Open Access
3 Citations
4,285 Views
11 Pages

The Desmoplakin Phenotype Spectrum: Is the Inflammation the “Fil Rouge” Linking Myocarditis, Arrhythmogenic Cardiomyopathy, and Uncommon Autoinflammatory Systemic Disease?

  • Saverio D’Elia,
  • Adriano Caputo,
  • Francesco Natale,
  • Enrica Pezzullo,
  • Giuseppe Limongelli,
  • Paolo Golino,
  • Giovanni Cimmino and
  • Francesco S. Loffredo

22 September 2024

Myocarditis is an inflammatory condition of cardiac tissue presenting significant variability in clinical manifestations and outcomes. Its etiology is diverse, encompassing infectious agents (primarily viruses, but also bacteria, protozoa, and helmin...

  • Article
  • Open Access
5 Citations
1,678 Views
18 Pages

Silicon Modifies Photosynthesis Efficiency and hsp Gene Expression in European Beech (Fagus sylvatica) Seedlings Exposed to Drought Stress

  • Justyna Nowakowska,
  • Monika Dang,
  • Piotr Kiełtyk,
  • Marzena Niemczyk,
  • Tadeusz Malewski,
  • Wiesław Szulc,
  • Beata Rutkowska,
  • Piotr Borowik and
  • Tomasz Oszako

21 September 2024

Background: Climate change is leading to severe and long-term droughts in European forest ecosystems. can have profound effects on various physiological processes, including photosynthesis, gene expression patterns, and nutrient uptake at the develop...

  • Article
  • Open Access
2,161 Views
19 Pages

21 September 2024

Background/Objectives: Transgene applications, ranging from gene therapy to the development of stable cell lines and organisms, rely on maintaining the expression of transgenes. To date, the use of plasmid-based transgenes has been limited by the los...

  • Review
  • Open Access
9 Citations
8,519 Views
50 Pages

Menin in Cancer

  • Ariana D. Majer,
  • Xianxin Hua and
  • Bryson W. Katona

21 September 2024

The protein menin is encoded by the MEN1 gene and primarily serves as a nuclear scaffold protein, regulating gene expression through its interaction with and regulation of chromatin modifiers and transcription factors. While the scope of menin’...

  • Article
  • Open Access
1,885 Views
16 Pages

Toll-like Receptor Expression in Pelodiscus sinensis Reveals Differential Responses after Aeromonas hydrophila Infection

  • Yu Tian,
  • Hui Zhang,
  • Lingrui Ge,
  • Zi’ao Wang,
  • Pei Wang,
  • Shuting Xiong,
  • Xiaoqing Wang and
  • Yazhou Hu

20 September 2024

Background: Toll-like receptor (TLR), as an important pattern recognition receptor, is a bridge between non-specific immunity and specific immunity, and plays a vital role in the disease resistance of aquatic animals. However, the function of TLR in...

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Genes - ISSN 2073-4425