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Genes, Volume 15, Issue 6

June 2024 - 171 articles

Cover Story: Endopeptidase CLPP and unfoldase CLPX are conserved since bacteria, as they are crucial for stress resistance and longevity. In humans, damage of mitochondria with impaired proteostasis leads to age-associated pathology and limited lifespan, with the most frequent disorder being Parkinson’s disease (PD). CLPP was implicated in PD, and it seemed easier to identify mitochondrial matrix targets of the CLPXP proteolytic machine, rather than cytosolic targets of PD-associated kinase PINK1 or ubiquitin ligase Parkin. Furthermore, CLPP-null mice have strong phenotypes including progressive neurodegeneration, while PINK1/Parkin-null mice show only discrete deficits. Neuroinflammation stood out in all three mutants, occurring early in CLPP-null mice, so its mechanism was defined in the cGAS-STING pathway. View this paper
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Articles (171)

  • Feature Paper
  • Article
  • Open Access
4 Citations
2,112 Views
13 Pages

20 June 2024

Chickpea (Cicer arietinum) is a major food legume providing high quality nutrition, especially in developing regions. Chickpea wilt (Fusarium oxysporum f. sp. ciceris) causes significant annual losses. Integrated disease management of Fusarium wilt i...

  • Article
  • Open Access
3 Citations
2,407 Views
16 Pages

Correlation Analysis of Genetic Mutations and Galectin Levels in Breast Cancer Patients

  • Ella G. Markalunas,
  • David H. Arnold,
  • Avery T. Funkhouser,
  • Julie C. Martin,
  • Michael Shtutman,
  • W. Jeffery Edenfield and
  • Anna V. Blenda

20 June 2024

Galectins are innate immune system regulators associated with disease progression in cancer. This paper aims to investigate the correlation between mutated cancer-critical genes and galectin levels in breast cancer patients to determine whether galec...

  • Article
  • Open Access
1 Citations
1,498 Views
11 Pages

Establishment and Application of a Novel Genetic Detection Panel for SNPs in Mongolian Gerbils

  • Yafang Guo,
  • Yutong Cui,
  • Minghe Sun,
  • Xiao Zhu,
  • Yilang Zhang,
  • Jing Lu,
  • Changlong Li,
  • Jianyi Lv,
  • Meng Guo and
  • Xin Liu
  • + 3 authors

20 June 2024

The Mongolian gerbil is a distinctive experimental animal in China, as its genetic qualities possess significant value in the field of medical biology research. Here, we aimed to establish an economical and efficient panel for genetic quality detecti...

  • Article
  • Open Access
3 Citations
1,709 Views
8 Pages

Extensive Contact Lens Wear Modulates Expression of miRNA-320 and miRNA-423-5p in the Human Corneal Epithelium: Possible Biomarkers of Corneal Health and Environmental Impact

  • Anna M. Roszkowska,
  • M’hammed Aguennouz,
  • Emanuela Aragona,
  • Romana Gargano,
  • Giovanni William Oliverio,
  • Leandro Inferrera and
  • Pasquale Aragona

20 June 2024

The identification of new biomarkers of ocular diseases is nowadays of outmost importance both for early diagnosis and treatment. Epigenetics is a rapidly growing emerging area of research and its involvement in the pathophysiology of ocular disease...

  • Article
  • Open Access
2 Citations
1,718 Views
14 Pages

Characterization and Comparative Analysis of Complete Chloroplast Genomes of Four Bromus (Poaceae, Bromeae) Species

  • Shichao Li,
  • Chunyu Tian,
  • Haihong Hu,
  • Yanting Yang,
  • Huiling Ma,
  • Qian Liu,
  • Lemeng Liu,
  • Zhiyong Li and
  • Zinian Wu

20 June 2024

Bromus (Poaceae Bromeae) is a forage grass with high adaptability and ecological and economic value. Here, we sequenced Bromus ciliatus, Bromus benekenii, Bromus riparius, and Bromus rubens chloroplast genomes and compared them with four previously d...

  • Article
  • Open Access
2 Citations
2,588 Views
10 Pages

Whole-Genome Analysis of Extensively Drug-Resistant Enterobacter hormaechei Isolated from a Patient with Non-Hodgkin’s Lymphoma

  • Cristina Motta Ferreira,
  • Felipe Gomes Naveca,
  • Guilherme Motta Antunes Ferreira,
  • Maria de Nazaré Saunier Barbosa,
  • Victor Costa de Souza,
  • Franceline Oliveira Calheiros,
  • Vander Silva Souza and
  • William Antunes Ferreira

20 June 2024

Background: Currently, the Enterobacteriaceae species are responsible for a variety of serious infections and are already considered a global public health problem, especially in underdeveloped countries, where surveillance and monitoring programs ar...

  • Article
  • Open Access
2 Citations
2,404 Views
11 Pages

Associations of Maternal Breastmilk microRNAs and Infant Obesity Status at 1 Year

  • Emily Van Syoc,
  • Molly Stegman,
  • Rhea Sullivan,
  • Alexandra Confair,
  • Kaitlyn Warren and
  • Steven D. Hicks

20 June 2024

Infant consumption of human milk (HM) is associated with a reduced risk of overweight and obesity, but the reasons for this relationship are not completely understood. There is emerging evidence that micro RNAs (miRNAs) regulate infant development an...

  • Article
  • Open Access
2 Citations
1,563 Views
15 Pages

19 June 2024

Eggshell color plays important biological roles and attracts the attention of both egg retailers and researchers. However, whether non-coding RNAs are involved in pigment deposition among different eggshell colors remains unknown. In this study, RNA...

  • Article
  • Open Access
1 Citations
1,799 Views
12 Pages

19 June 2024

Green eggs are mainly caused by inserting an avian endogenous retrovirus (EVA-HP) fragment into the SLCO1B3 gene. Although the genotypes for this insertion allele are consistent, eggshell color (ESC) may vary after a peak laying period; light-colored...

  • Article
  • Open Access
1 Citations
2,242 Views
20 Pages

19 June 2024

Brain lipid homeostasis is an absolute requirement for proper functionality of nerve cells and neurological performance. Current evidence demonstrates that lipid alterations are linked to neurodegenerative diseases, especially Alzheimer’s disea...

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Genes - ISSN 2073-4425