Next Article in Journal
A Functional Carbohydrate Degrading Enzyme Potentially Acquired by Horizontal Gene Transfer in the Genome of the Soil Invertebrate Folsomia candida
Previous Article in Journal
Qualitative and Quantitative Detection of Mealworm DNA in Raw and Commercial Food Products Using Real-Time PCR
 
 
Article

What Causes Cancer in Women with a gBRCA Pathogenic Variant? Counselees’ Causal Attributions and Associations with Perceived Control

1
Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt—Universität zu Berlin, and Berlin Institute of Health, Gender in Medicine, Charitéplatz 1, 10117 Berlin, Germany
2
Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt—Universität zu Berlin, and Berlin Institute of Health, Institute of Biometry and Clinical Epidemiology, Charitéplatz 1, 10177 Berlin, Germany
3
Division of Ergonomics, Department of Psychology and Ergonomics (IPA), Technische Universität Berlin, Marchstr. 23, 10587 Berlin, Germany
4
Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt—Universität zu Berlin, and Berlin Institute of Health, Hereditary Breast and Ovarian Cancer Center, Charitéplatz 1, 10117 Berlin, Germany
*
Author to whom correspondence should be addressed.
F.K. and K.K. are shared first authors.
Academic Editor: Maciej Wnuk
Genes 2022, 13(8), 1399; https://doi.org/10.3390/genes13081399
Received: 28 June 2022 / Revised: 29 July 2022 / Accepted: 3 August 2022 / Published: 6 August 2022
(This article belongs to the Section Molecular Genetics and Genomics)
Laypersons have a strong need to explain critical life events, such as the development of an illness. Expert explanations do not always match the beliefs of patients. We therefore assessed causal attributions made by women with a pathogenic germline variant in BRCA1/2 (gBRCA1/2-PV), both with and without a cancer diagnosis. We assumed that attributions would be associated with the control experience. We conducted a cross-sectional study of N = 101 women with a gBRCA1/2-PV (mean age 43.3 ± 10.9). Women answered self-report questionnaires on perceived causes and control. Most women (97%) named genes as a causal factor for the development of cancer. Surprisingly, the majority of women also named stress and health behavior (both 81%), environment (80%), and personality (61%). Women with a cancer diagnosis tended to endorse more causes. The attributions to personality (ρ = 0.39, p < 0.01) health behavior (ρ = 0.44, p < 0.01), and environment (ρ = 0.22, p < 0.05) were significantly associated with personal control, whereas attribution to genes showed a small, albeit significant association with treatment control (ρ = 0.20, p < 0.05). Discussing causal beliefs in clinical counseling may provide a “window of opportunity” in which risk factors and health behaviors could be better addressed and individually targeted. View Full-Text
Keywords: hereditary breast and ovarian cancer; gBRCA1/2-PV; causal attributions; personal control; genetic counseling hereditary breast and ovarian cancer; gBRCA1/2-PV; causal attributions; personal control; genetic counseling
Show Figures

Figure 1

MDPI and ACS Style

Kendel, F.; Klein, K.; Schüürhuis, S.; Besch, L.; Feufel, M.A.; Speiser, D. What Causes Cancer in Women with a gBRCA Pathogenic Variant? Counselees’ Causal Attributions and Associations with Perceived Control. Genes 2022, 13, 1399. https://doi.org/10.3390/genes13081399

AMA Style

Kendel F, Klein K, Schüürhuis S, Besch L, Feufel MA, Speiser D. What Causes Cancer in Women with a gBRCA Pathogenic Variant? Counselees’ Causal Attributions and Associations with Perceived Control. Genes. 2022; 13(8):1399. https://doi.org/10.3390/genes13081399

Chicago/Turabian Style

Kendel, Friederike, Katharina Klein, Stephen Schüürhuis, Laura Besch, Markus A. Feufel, and Dorothee Speiser. 2022. "What Causes Cancer in Women with a gBRCA Pathogenic Variant? Counselees’ Causal Attributions and Associations with Perceived Control" Genes 13, no. 8: 1399. https://doi.org/10.3390/genes13081399

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop