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Article

Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver

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Division of Pediatric Otolaryngology-Head and Neck Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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Department of Pediatrics, Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
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Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal
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Department of Biology, College of Arts and Sciences, University of Dayton, Dayton, OH 45469, USA
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Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
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Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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The Sleep Center, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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The Center for Circadian Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
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Author to whom correspondence should be addressed.
Academic Editor: Vladimir Korinek
Genes 2021, 12(10), 1627; https://doi.org/10.3390/genes12101627
Received: 20 September 2021 / Revised: 11 October 2021 / Accepted: 15 October 2021 / Published: 16 October 2021
(This article belongs to the Special Issue Genetics of Circadian Clocks in Eukaryotic Organisms)
At least one-third of adults in the United States experience intermittent hypoxia (IH) due to health or living conditions. The majority of these adults suffer with sleep breathing conditions and associated circadian rhythm disorders. The impact of IH on the circadian clock is not well characterized. In the current study, we used an IH mouse model to understand the impact of IH on the circadian gene expression of the canonical clock genes in the central (the brain) and peripheral (the liver) tissues. Gene expression was measured using a Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). CircaCompare was used to evaluate the differential rhythmicity between normoxia and IH. Our observations suggested that the circadian clock in the liver was less sensitive to IH compared to the circadian clock in the brain. View Full-Text
Keywords: intermittent hypoxia; circadian rhythms; canonical clock genes intermittent hypoxia; circadian rhythms; canonical clock genes
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MDPI and ACS Style

Koritala, B.S.C.; Lee, Y.Y.; Bhadri, S.S.; Gaspar, L.S.; Stanforth, C.; Wu, G.; Ruben, M.D.; Francey, L.J.; Smith, D.F. Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver. Genes 2021, 12, 1627. https://doi.org/10.3390/genes12101627

AMA Style

Koritala BSC, Lee YY, Bhadri SS, Gaspar LS, Stanforth C, Wu G, Ruben MD, Francey LJ, Smith DF. Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver. Genes. 2021; 12(10):1627. https://doi.org/10.3390/genes12101627

Chicago/Turabian Style

Koritala, Bala S.C., Yin Y. Lee, Shweta S. Bhadri, Laetitia S. Gaspar, Corinne Stanforth, Gang Wu, Marc D. Ruben, Lauren J. Francey, and David F. Smith 2021. "Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver" Genes 12, no. 10: 1627. https://doi.org/10.3390/genes12101627

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