Genetics of Circadian Clocks in Eukaryotic Organisms

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (25 August 2022) | Viewed by 3521

Special Issue Editor

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Guest Editor
Department of Physiology and Functional Genomics, University of Florida, 1345 Center Drive, Gainesville, FL 32603, USA
Interests: circadian rhythms; biochemistry; genetics; molecular biology; functional genomics; nutrient sensing; neuroinflammation; physiology; sleep homeostasis

Special Issue Information

Dear Colleagues,

Circadian rhythms play broad and important roles in metabolism, physiology, and behavior. Circadian clock research stands as one of the greatest success stories in biology. It started out with descriptive studies of behavior at the organism level and later matured into the elaboration of cellular and molecular mechanisms. Almost all organisms on the planet exhibit circadian rhythms, and a full force of genetic, molecular, and genomic studies have led to the identification of many genes that make up the clockwork. The 2017 Nobel Prize in Physiology or Medicine was awarded to three scientists for their contributions to the discoveries of molecular mechanisms controlling the circadian rhythm in fruit flies. These studies reveal that the design principle is highly conserved, although the players may have diverged among the systems. While the basic clock mechanism is widely accepted, there are additional players that are either part of the core clock mechanism or serve as modifiers that link cell physiology to the clockwork. Heuristically, while a complex system functions to ensure proper systems function, it may incur vulnerability in diseases and chronic conditions.

This Special Issue on “Genetics of Circadian Clocks in Eukaryotic Organisms” is intended to provide a platform for a wide range of reviews and research articles related to the genetics, molecular biology, and genomics of several eukaryotic model organisms. The progress in this area of research promises to shape the future of circadian rhythm research and ultimately offer novel chronotherapeutic avenues in clinical practice. Please contact the Guest Editors with questions related to the scope of this Special Issue.

Dr. Andrew C. Liu
Guest Editor

Manuscript Submission Information

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  • Circadian clock
  • Circadian rhythms
  • Transcriptional negative feedback
  • Post-translational regulation
  • Signal transduction
  • Genetics
  • Cell and molecular biology
  • Genomics

Published Papers (1 paper)

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8 pages, 1320 KiB  
Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver
by Bala S. C. Koritala, Yin Yeng Lee, Shweta S. Bhadri, Laetitia S. Gaspar, Corinne Stanforth, Gang Wu, Marc D. Ruben, Lauren J. Francey and David F. Smith
Genes 2021, 12(10), 1627; (registering DOI) - 16 Oct 2021
Cited by 8 | Viewed by 2955
At least one-third of adults in the United States experience intermittent hypoxia (IH) due to health or living conditions. The majority of these adults suffer with sleep breathing conditions and associated circadian rhythm disorders. The impact of IH on the circadian clock is [...] Read more.
At least one-third of adults in the United States experience intermittent hypoxia (IH) due to health or living conditions. The majority of these adults suffer with sleep breathing conditions and associated circadian rhythm disorders. The impact of IH on the circadian clock is not well characterized. In the current study, we used an IH mouse model to understand the impact of IH on the circadian gene expression of the canonical clock genes in the central (the brain) and peripheral (the liver) tissues. Gene expression was measured using a Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). CircaCompare was used to evaluate the differential rhythmicity between normoxia and IH. Our observations suggested that the circadian clock in the liver was less sensitive to IH compared to the circadian clock in the brain. Full article
(This article belongs to the Special Issue Genetics of Circadian Clocks in Eukaryotic Organisms)
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