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RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

1
Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 143 00 Prague, Czech Republic
2
Department of Cell Biology, Charles University, Vinicna 7, 128 43 Prague, Czech Republic
3
Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Genes 2020, 11(2), 232; https://doi.org/10.3390/genes11020232
Received: 31 January 2020 / Revised: 14 February 2020 / Accepted: 18 February 2020 / Published: 21 February 2020
(This article belongs to the Special Issue DNA Helicases: Mechanisms, Biological Pathways, and Disease Relevance)
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development. View Full-Text
Keywords: RECQ5; transcription-replication conflicts; replication stress; R-loops; DNA repair; genomic instability RECQ5; transcription-replication conflicts; replication stress; R-loops; DNA repair; genomic instability
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Andrs, M.; Hasanova, Z.; Oravetzova, A.; Dobrovolna, J.; Janscak, P. RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription. Genes 2020, 11, 232.

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