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Reconstituting the Mammalian Apoptotic Switch in Yeast

Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH-1, Ilkovičova 6, 84215 Bratislava, Slovakia
Author to whom correspondence should be addressed.
Genes 2020, 11(2), 145;
Received: 14 January 2020 / Revised: 28 January 2020 / Accepted: 28 January 2020 / Published: 29 January 2020
(This article belongs to the Special Issue Humanized Yeast Models)
Proteins of the Bcl-2 family regulate the permeabilization of the mitochondrial outer membrane that represents a crucial irreversible step in the process of induction of apoptosis in mammalian cells. The family consists of both proapoptotic proteins that facilitate the membrane permeabilization and antiapoptotic proteins that prevent it in the absence of an apoptotic signal. The molecular mechanisms, by which these proteins interact with each other and with the mitochondrial membranes, however, remain under dispute. Although yeast do not have apparent homologues of these apoptotic regulators, yeast cells expressing mammalian members of the Bcl-2 family have proved to be a valuable model system, in which action of these proteins can be effectively studied. This review focuses on modeling the activity of proapoptotic as well as antiapoptotic proteins of the Bcl-2 family in yeast.
Keywords: apoptosis; Saccharomyces cerevisiae; Bcl-2 protein family; Bax; Bcl-XL; BH3-only proteins; mitochondria apoptosis; Saccharomyces cerevisiae; Bcl-2 protein family; Bax; Bcl-XL; BH3-only proteins; mitochondria
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Polčic, P.; Mentel, M. Reconstituting the Mammalian Apoptotic Switch in Yeast. Genes 2020, 11, 145.

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